Rabbit PTPN3 Polyclonal Antibody | anti-PTPN3 antibody

PTPN3 antibody

Cat. Num. AAA9413208

• Gene Names: PTPN3; PTPH1; PTP-H1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Antibodies were purified by affinity purification using immunogen.
• Synonyms: PTPN3; Polyclonal Antibody; PTPN3 antibody; PTPH1; PTP-H1; anti-PTPN3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total PTPN3 antibody.
• Purity/Purification: Antibodies were purified by affinity purification using immunogen.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 868

• Applicable Applications for anti-PTPN3 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500 - 1:2000
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant protein of human PTPN3.
• Target Name: PTPN3
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using PTPN3 antibody.)

Related Product Information for anti-PTPN3 antibody

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-PTPN3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 223941879
• NCBI GeneID: 5774
• NCBI Accession #: NP_001138840.1
• NCBI GenBank Nucleotide #: NM_001145368.1
• UniProt Accession #: P26045; A0AUW9; E7EN99; E9PGU7
• Molecular Weight: 83,723 Da
• NCBI Official Full Name: tyrosine-protein phosphatase non-receptor type 3 isoform 2
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, non-receptor type 3
• NCBI Official Symbol: PTPN3
• NCBI Official Synonym Symbols: PTPH1; PTP-H1
• NCBI Protein Information: tyrosine-protein phosphatase non-receptor type 3
• UniProt Protein Name: Tyrosine-protein phosphatase non-receptor type 3
• Protein Family: Tyrosine-protein phosphatase non-receptor
• UniProt Gene Name: PTPN3
• UniProt Synonym Gene Names: PTPH1; PTP-H1
• UniProt Entry Name: PTN3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Uniprot Description

PTPN3: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity. Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)

Chromosomal Location of Human Ortholog: 9q31

Cellular Component: internal side of plasma membrane; cytoskeleton; cytoplasm

Molecular Function: protein binding; sodium channel regulator activity; phosphotyrosine binding; cytoskeletal protein binding; protein tyrosine phosphatase activity; ATPase binding

Biological Process: negative regulation of mitotic cell cycle; negative regulation of membrane protein ectodomain proteolysis; protein amino acid dephosphorylation