Rabbit anti-Human, Mouse PTP gamma Polyclonal Antibody | anti-PTPRG antibody

PTP gamma, ID (Receptor-type Tyrosine-protein Phosphatase gamma, Protein-tyrosine Phosphatase gamma, R-PTP-gamma, PTPRG, PTPG) (MaxLight 490)

Cat. Num. AAA6495802

• Gene Names: PTPRG; PTPG; HPTPG; RPTPG; R-PTP-GAMMA
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A/G Affinity Chromatography.
• Synonyms: PTP gamma; Polyclonal Antibody; ID (Receptor-type Tyrosine-protein Phosphatase gamma; Protein-tyrosine Phosphatase gamma; R-PTP-gamma; PTPRG; PTPG) (MaxLight 490); anti-PTPRG antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PTP gamma. Species Crossreactivity: mouse
• Purity/Purification: Purified by Protein A/G Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-PTPRG antibody: FLISA, Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 751-782 in the central region of human PTP gamma, UniProt Accession # P24370.
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot to detect PTP gamma in mouse brain tissue lysate usingMBS629408.)

Related Product Information for anti-PTPRG antibody

PTPgamma is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. The gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.

Product Categories/Family for anti-PTPRG antibody

Antibodies; Enzymes; Phosphatase

References

1. Liu, S., et al., Breast Cancer Res. Treat. 71(1):21-35 (2002). 2. Kastury, K., et al., Genomics 32(2):225-235 (1996). 3. Barnea, G., et al., Mol. Cell. Biol. 13(3):1497-1506 (1993). 4. LaForgia, S., et al., Proc. Natl. Acad. Sci. USA 88(11):5036-5040 (1991). 5. Krueger, N.X., et al., EMBO J. 9(10):3241-3252 (1990).

NCBI and Uniprot Product Information

• NCBI GI #: 219520138
• NCBI GeneID: 5793
• UniProt Accession #: P23470; Q15623; Q59EE0; Q68DU5; B2RU12; B7ZLX5
• Molecular Weight: 158,771 Da
• NCBI Official Full Name: PTPRG protein
• NCBI Official Synonym Full Names: protein tyrosine phosphatase, receptor type G
• NCBI Official Symbol: PTPRG
• NCBI Official Synonym Symbols: PTPG; HPTPG; RPTPG; R-PTP-GAMMA
• NCBI Protein Information: receptor-type tyrosine-protein phosphatase gamma
• UniProt Protein Name: Receptor-type tyrosine-protein phosphatase gamma
• Protein Family: Receptor-type tyrosine-protein phosphatase
• UniProt Gene Name: PTPRG
• UniProt Synonym Gene Names: PTPG; Protein-tyrosine phosphatase gamma; R-PTP-gamma

NCBI Description

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Possesses tyrosine phosphatase activity.