Western Blot (WB)
(Mouse Ptk2b Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Ptk2b antibody detected the Ptk2b protein (arrow).)
Rabbit anti-Human, mouse Ptk2b Polyclonal Antibody | anti-Ptk2b antibody
Mouse Ptk2b Antibody (Center)
Western Blot (WB)
(Mouse Ptk2b Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Ptk2b antibody detected the Ptk2b protein (arrow).)
Western Blot (WB)
(Mouse Ptk2b Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Ptk2b antibody detected the Ptk2b protein (arrow).)
Western Blot (WB)
(Mouse Ptk2b Antibody (Center) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Ptk2b antibody detected the Ptk2b protein (arrow).)
Western Blot (WB)
(Mouse Ptk2b Antibody (Center) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Ptk2b antibody detected the Ptk2b protein (arrow).)
Immunohistochemistry (IHC)
(Mouse Ptk2b Antibody (Center) (MBS9213158)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Ptk2b Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Mouse Ptk2b Antibody (Center) (MBS9213158)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Ptk2b Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
NCBI and Uniprot Product Information
Uniprot Description
Pyk2: a nonreceptor tyrosine kinase of the Fak family. Predominantly expressed in the cells derived from hematopoietic lineages and in the central nervous system. Pyk2 is one of the signaling mediators for G-protein-coupled receptors. Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. It plays an important role in cell motility such as spreading and migration. Two alternatively spliced isoforms have been described.
Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Nuclear receptor co-regulator; Protein kinase, TK; TK group; Fak family
Cellular Component: focal adhesion; postsynaptic density; dendrite; cell cortex; cytosol; lipid raft; N-methyl-D-aspartate selective glutamate receptor complex; nucleoplasm; extrinsic to internal side of plasma membrane; growth cone; cytoskeleton; cell projection; membrane; cell soma; lamellipodium; axon; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cell junction; nucleus
Molecular Function: calmodulin-dependent protein kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein kinase activity; transferase activity; signal transducer activity; protein binding; protein-tyrosine kinase activity; N-methyl-D-aspartate selective glutamate receptor activity; 3-phosphoinositide-dependent protein kinase binding; transferase activity, transferring phosphorus-containing groups; protein complex binding; kinase activity; ATP binding; receptor binding
Biological Process: focal adhesion formation; positive regulation of JNK activity; regulation of nitric oxide biosynthetic process; regulation of cGMP biosynthetic process; protein amino acid phosphorylation; regulation of cell shape; regulation of inositol trisphosphate biosynthetic process; negative regulation of bone mineralization; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; tumor necrosis factor-mediated signaling pathway; negative regulation of ossification; negative regulation of neuron apoptosis; cell adhesion; neurite development; bone resorption; negative regulation of myeloid cell differentiation; positive regulation of nitric-oxide synthase activity; actin filament organization; positive regulation of cell growth; marginal zone B cell differentiation; positive regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; ionotropic glutamate receptor signaling pathway; negative regulation of apoptosis; activation of JAK protein; peptidyl-tyrosine phosphorylation; blood vessel endothelial cell migration; positive regulation of translation; negative regulation of potassium ion transport; positive regulation of JNK cascade; regulation of calcium-mediated signaling; positive regulation of synaptic transmission, glutamatergic; negative regulation of cell proliferation; positive regulation of cell proliferation; angiogenesis; positive regulation of cell-matrix adhesion; integrin-mediated signaling pathway; epidermal growth factor receptor signaling pathway; regulation of cell adhesion; immune system process; MAPKKK cascade; signal complex assembly; positive regulation of phosphoinositide 3-kinase activity; oocyte maturation; regulation of release of sequestered calcium ion into cytosol; positive regulation of actin filament polymerization; response to hydrogen peroxide; positive regulation of protein kinase activity; stress fiber formation; cellular defense response; innate immune response; sprouting angiogenesis; vascular endothelial growth factor receptor signaling pathway; phosphorylation; positive regulation of cell migration
Research Articles on Ptk2b
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Product Notes
The Ptk2b ptk2b (Catalog #AAA9213158) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 672-701. The Mouse Ptk2b Antibody (Center) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Ptk2b can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the Ptk2b ptk2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ptk2b, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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