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Western Blot (WB) (Western blot analysis of extracts from HT-29 cells, using PTGR1 antibody.)

Rabbit anti-Human PTGR1 Polyclonal Antibody | anti-PTGR1 antibody

PTGR1 Antibody

Gene Names
PTGR1; PGR1; ZADH3; LTB4DH
Reactivity
Human
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
PTGR1; Polyclonal Antibody; PTGR1 Antibody; Prostaglandin reductase 1; PRG-1; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; EC=1.3.1.74; 15-oxoprostaglandin 13-reductase; anti-PTGR1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total PTGR1 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
329
Applicable Applications for anti-PTGR1 antibody
Western Blot (WB)
Application Notes
Western blotting: 1:500~1:3000
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from internal of human PTGR1.
Target Name
PTGR1
Preparation and Storage
Store at -20 degree C

Western Blot (WB)

(Western blot analysis of extracts from HT-29 cells, using PTGR1 antibody.)

Western Blot (WB) (Western blot analysis of extracts from HT-29 cells, using PTGR1 antibody.)
Related Product Information for anti-PTGR1 antibody
Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha By similarity. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4.Humphray S.J., Nature 429:369-374(2004).The MGC Project Team; Genome Res. 14:2121-2127(2004).Yokomizo T., J. Biol. Chem. 271:2844-2850(1996)
Product Categories/Family for anti-PTGR1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
32,895 Da
NCBI Official Full Name
prostaglandin reductase 1 isoform 1
NCBI Official Synonym Full Names
prostaglandin reductase 1
NCBI Official Symbol
PTGR1
NCBI Official Synonym Symbols
PGR1; ZADH3; LTB4DH
NCBI Protein Information
prostaglandin reductase 1
UniProt Protein Name
Prostaglandin reductase 1
Protein Family
UniProt Gene Name
PTGR1
UniProt Synonym Gene Names
LTB4DH; PRG-1
UniProt Entry Name
PTGR1_HUMAN

NCBI Description

This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Uniprot Description

LTB4DH: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. Belongs to the NADP-dependent oxidoreductase L4BD family.

Protein type: EC 1.3.1.48; Oxidoreductase; EC 1.3.1.74

Chromosomal Location of Human Ortholog: 9q31.3

Cellular Component: cytoplasm

Molecular Function: 15-oxoprostaglandin 13-oxidase activity; zinc ion binding; 2-alkenal reductase activity

Biological Process: response to toxin; cyclooxygenase pathway; arachidonic acid metabolic process; leukotriene metabolic process

Research Articles on PTGR1

Similar Products

Product Notes

The PTGR1 ptgr1 (Catalog #AAA9408924) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTGR1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PTGR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500~1:3000. Researchers should empirically determine the suitability of the PTGR1 ptgr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTGR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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