Rabbit anti-Human PTGES3 Polyclonal Antibody | anti-PTGES3 antibody

PTGES3, ID (PTGES3, P23, TEBP, Prostaglandin E synthase 3, Cytosolic prostaglandin E2 synthase, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23) (MaxLight 650)

Cat. Num. AAA6338708

• Gene Names: PTGES3; P23; TEBP; cPGES
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PTGES3; Polyclonal Antibody; ID (PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23) (MaxLight 650); Telomerase-binding protein p23; anti-PTGES3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-PTGES3 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: PTGES3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-73 amino acids from the Central region of human PTGES3.
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-PTGES3 antibody

Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes.

Product Categories/Family for anti-PTGES3 antibody

Antibodies; Prostaglandins

References

Chen, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7401-7406(2010). Lee, J.H., et al. Cancer Lett. 290(1):76-86(2010). Chadli, A., et al. J. Biol. Chem. 285(6):4224-4231(2010). Woo, S.H., et al. J. Biol. Chem. 284(45):30871-30880(2009). Mattila, S., et al. Neuropathology 29(2):156-165(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 23308579
• NCBI GeneID: 10728
• NCBI Accession #: NP_006592.3
• NCBI GenBank Nucleotide #: NM_006601.5
• UniProt Accession #: Q15185; Q8WU70; A8K7D0
• Molecular Weight: 18,697 Da
• NCBI Official Full Name: prostaglandin E synthase 3
• NCBI Official Synonym Full Names: prostaglandin E synthase 3 (cytosolic)
• NCBI Official Symbol: PTGES3
• NCBI Official Synonym Symbols: P23; TEBP; cPGES
• NCBI Protein Information: prostaglandin E synthase 3; Hsp90 co-chaperone; telomerase-binding protein p23; progesterone receptor complex p23; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; unactive progesterone receptor, 23 kD
• UniProt Protein Name: Prostaglandin E synthase 3
• Protein Family: Prostaglandin E synthase
• UniProt Gene Name: PTGES3
• UniProt Synonym Gene Names: P23; TEBP; cPGES
• UniProt Entry Name: TEBP_HUMAN

Uniprot Description

TEBP: Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor- mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Belongs to the p23/wos2 family.

Protein type: Transferase; Isomerase; Chaperone; Nuclear receptor co-regulator; EC 5.3.99.3

Chromosomal Location of Human Ortholog: 12q13.3|12

Cellular Component: nucleoplasm; chromosome, telomeric region; telomerase holoenzyme complex; cytoplasm; nucleus; cytosol

Molecular Function: telomerase activity; protein binding; unfolded protein binding; prostaglandin-E synthase activity

Biological Process: RNA-dependent DNA replication; cyclooxygenase pathway; arachidonic acid metabolic process; prostaglandin biosynthetic process; signal transduction; telomere maintenance