Western Blot (WB)
(Western Blot analysis of Raji cell using PTGER4 Polyclonal Antibody at dilution of 1:450)
Rabbit PTGER4 Polyclonal Antibody | anti-PTGER4 antibody
PTGER4 Polyclonal Antibody
Western Blot (WB)
(Western Blot analysis of Raji cell using PTGER4 Polyclonal Antibody at dilution of 1:450)
Western Blot (WB)
(Western Blot analysis of Raji cell using PTGER4 Polyclonal Antibody at dilution of 1:450)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
Uniprot Description
PTGER4: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Belongs to the G-protein coupled receptor 1 family.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component: integral to membrane; plasma membrane
Molecular Function: protein binding; prostaglandin E receptor activity
Biological Process: T-helper cell differentiation; negative regulation of cytokine secretion; response to lipopolysaccharide; negative regulation of integrin activation; G-protein signaling, coupled to cAMP nucleotide second messenger; response to mechanical stimulus; negative regulation of inflammatory response; regulation of stress fiber formation; JNK cascade; immune response; regulation of ossification; positive regulation of cytokine secretion; positive regulation of inflammatory response
Research Articles on PTGER4
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Product Notes
The PTGER4 ptger4 (Catalog #AAA2524484) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PTGER4 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PTGER4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the PTGER4 ptger4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PTGER4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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