Rabbit anti-Human, Mouse PTEN-induced Kinase 1 Polyclonal Antibody | anti-PINK1 antibody

PTEN-induced Kinase 1 (PTEN-induced Putative Kinase 1, PTEN-induced Putative Kinase Protein 1, PINK1, PINK-1, BRPK, FLJ27236, PARK6, Serine/threonine Protein Kinase PINK1 Mitochondrial)

Cat. Num. AAA616789

• Gene Names: PINK1; BRPK; PARK6
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: PTEN-induced Kinase 1; Polyclonal Antibody; PTEN-induced Kinase 1 (PTEN-induced Putative Kinase 1; PTEN-induced Putative Kinase Protein 1; PINK1; PINK-1; BRPK; FLJ27236; PARK6; Serine/threonine Protein Kinase PINK1 Mitochondrial); Anti -PTEN-induced Kinase 1 (PTEN-induced Putative Kinase 1; anti-PINK1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Tris-citrate/phosphate, [pH7-8].

• Applicable Applications for anti-PINK1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: An N-terminal region synthetic peptide made to the human Pink1 protein sequence (between residues 1-50). Homology: 100% homology with human and mouse protein.
• Cellular Localization: Mitochondrion.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-PINK1 antibody

Phosphatase and Tensin Homolog (PTEN) dephosphorylates lipids. Malfunctions in this contribute to many human cancers. PTEN induced putative kinase 1 (Pink1) was first discovered when researching the PTEN signaling pathway, thus Pink1 is also involved in many human cancers. It is found in the mitochondria and its homozygous C-terminus mutation has been implicated in the early development of Parkinson's disease.

Product Categories/Family for anti-PINK1 antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 14149100
• NCBI GeneID: 65018
• UniProt Accession #: Q9BXM7; Q8N6T9; Q8NBU3; Q96DE4
• Molecular Weight: 62,769 Da
• NCBI Official Full Name: PTEN induced putative kinase 1
• NCBI Official Synonym Full Names: PTEN induced putative kinase 1
• NCBI Official Symbol: PINK1
• NCBI Official Synonym Symbols: BRPK; PARK6
• NCBI Protein Information: serine/threonine-protein kinase PINK1, mitochondrial; protein kinase BRPK; PTEN-induced putative kinase protein 1
• UniProt Protein Name: Serine/threonine-protein kinase PINK1, mitochondrial
• Protein Family: Serine/threonine-protein kinase
• UniProt Gene Name: PINK1
• UniProt Entry Name: PINK1_HUMAN

NCBI Description

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]

Uniprot Description

PINK1: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Interats with PARK2. Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, Other; Mitochondrial; Membrane protein, integral; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Other group; NKF2 family

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: mitochondrial outer membrane; cytoskeleton; membrane; mitochondrion; perinuclear region of cytoplasm; axon; cytoplasm; mitochondrial inner membrane; TORC2 complex; mitochondrial intermembrane space; nucleus; chromatin; cytosol; integral to mitochondrial outer membrane

Molecular Function: protein serine/threonine kinase activity; protein kinase B binding; protein binding; protease activator activity; protease binding; ubiquitin protein ligase binding; magnesium ion binding; kinase activity; ATP binding

Biological Process: ubiquitin-dependent protein catabolic process; positive regulation of dopamine secretion; negative regulation of JNK cascade; positive regulation of translation; regulation of protein ubiquitination; protein ubiquitination; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of macroautophagy; regulation of mitochondrial membrane potential; positive regulation of ubiquitin-protein ligase activity; response to stress; regulation of protein complex assembly; negative regulation of neuron apoptosis; regulation of hydrogen peroxide metabolic process; mitochondrion organization and biogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein stabilization; activation of protein kinase B; positive regulation of synaptic transmission, dopaminergic; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein kinase B signaling cascade; peptidyl-serine phosphorylation; mitochondrion degradation; positive regulation of transcription factor activity; response to oxidative stress; positive regulation of protein amino acid phosphorylation; phosphorylation

Disease: Parkinson Disease 6, Autosomal Recessive Early-onset