Rabbit anti-Human, Mouse PSMD7 Polyclonal Antibody | anti-PSMD7 antibody

PSMD7 Rabbit Polyclonal

Cat. Num. AAA7603126

• Gene Names: PSMD7; P40; S12; Rpn8; MOV34
• Reactivity: Human, Mouse
• Applications: ELISA, Immunofluorescence, Immunoprecipitation, Flow Cytometry, Functional Assay, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PSMD7; Polyclonal Antibody; PSMD7 Rabbit Polyclonal; anti-PSMD7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 326

• Applicable Applications for anti-PSMD7 antibody: ELISA (EIA), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FC/FACS), Western Blot (WB)
• Immunogen: Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse spleen using MBS7603126 (PSMD7 antibody) at dilution of 1:100)

Western Blot (WB)

(HepG2 cells were subjected to SDS PAGE followed by western blot with MBS7603126 (PSMD7 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 33875323
• NCBI GeneID: 5713
• Molecular Weight: 37,025 Da
• NCBI Official Full Name: PSMD7 protein, partial
• NCBI Official Synonym Full Names: proteasome 26S subunit, non-ATPase 7
• NCBI Official Symbol: PSMD7
• NCBI Official Synonym Symbols: P40; S12; Rpn8; MOV34
• NCBI Protein Information: 26S proteasome non-ATPase regulatory subunit 7
• UniProt Protein Name: 26S proteasome non-ATPase regulatory subunit 7
• Protein Family: 26S proteasome non-ATPase regulatory
• UniProt Gene Name: PSMD7
• UniProt Synonym Gene Names: MOV34L
• UniProt Entry Name: PSMD7_HUMAN

NCBI Description

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]

Uniprot Description

PSMD7: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Belongs to the peptidase M67A family.

Protein type: Protease; Proteasome complex

Chromosomal Location of Human Ortholog: 16q22.3

Cellular Component: cytosol; membrane; nucleoplasm; nucleus; proteasome complex; proteasome regulatory particle

Molecular Function: protein binding; protein homodimerization activity

Biological Process: anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; MAPKKK cascade; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of amino acid metabolic process; regulation of mRNA stability; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; tumor necrosis factor-mediated signaling pathway; Wnt receptor signaling pathway, planar cell polarity pathway