Western Blot (WB)
(WB: 3T3 cell lysate was probed with MBS620327 (2ug/ml). Arrow indicates Protein Phosphatase Methylesterase-1 (~44kD).)
Rabbit Protein Phosphatase Methylesterase Polyclonal Antibody | anti-PME1 antibody
Protein Phosphatase Methylesterase (PME 1) (MaxLight 750)
Not suitable for Immunoprecipitation on native PME-1.
Applications are based on unconjugated antibody.
Western Blot (WB)
(WB: 3T3 cell lysate was probed with MBS620327 (2ug/ml). Arrow indicates Protein Phosphatase Methylesterase-1 (~44kD).)
Western Blot (WB)
(WB: 3T3 cell lysate was probed with MBS620327 (2ug/ml). Arrow indicates Protein Phosphatase Methylesterase-1 (~44kD).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Uniprot Description
PPME1: Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. Belongs to the AB hydrolase superfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.1.89; Motility/polarity/chemotaxis; Hydrolase; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 11q13.4
Molecular Function: protein phosphatase 2A binding; protein phosphatase type 2A regulator activity; protein C-terminal methylesterase activity; protein phosphatase inhibitor activity; protein phosphatase binding
Biological Process: regulation of catalytic activity; negative regulation of catalytic activity; protein amino acid demethylation
Research Articles on PME1
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Product Notes
The PME1 ppme1 (Catalog #AAA6494041) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Protein Phosphatase Methylesterase (PME 1) (MaxLight 750) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Protein Phosphatase Methylesterase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1-4ug/ul of this lot detected PME-1 in RIPA lysates from mouse 3T3 fibroblasts. Not suitable for Immunoprecipitation on native PME-1. Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the PME1 ppme1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Protein Phosphatase Methylesterase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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