Immunohistochemistry (IHC)
(Anti-Progesterone Receptor Picoband antibody, MBS177029-1.JPGIHC(P): Human Mammary Cancer Tissue )
Rabbit anti-Human, Rat Progesterone Receptor Polyclonal Antibody | anti-PGR antibody
Anti-Progesterone Receptor antibody
Immunohistochemistry (IHC)
(Anti-Progesterone Receptor Picoband antibody, MBS177029-1.JPGIHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-Progesterone Receptor Picoband antibody, MBS177029-1.JPGIHC(P): Human Mammary Cancer Tissue )
Testing Data
(Anti-Progesterone Receptor Picoband antibody, MBS177029-2.jpgAll lanes: Anti-Progesterone Receptor(MBS177029) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: MCF-7 Whole Cell Lysate at 40ugLane 3: SKOV Whole Cell Lysate at 40ugLane 4: Rat Brain Tissue Lysate at 40ugLane 5: Rat Testis Tissue Lysate at 40ugPredicted bind size: 99KDObserved bind size: 99KD)
Testing Data
(Anti-Progesterone Receptor Picoband antibody, MBS177029-2.jpgAll lanes: Anti-Progesterone Receptor(MBS177029) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: MCF-7 Whole Cell Lysate at 40ugLane 3: SKOV Whole Cell Lysate at 40ugLane 4: Rat Brain Tissue Lysate at 40ugLane 5: Rat Testis Tissue Lysate at 40ugPredicted bind size: 99KDObserved bind size: 99KD)
Background: The progesterone receptor (PR) is an intracellular steroid receptor that specially binds progesterone in humans. PR has been a member of the steroid receptor superfamily. It is encoded by a single PGR gene residing on chromosome 11q22. The PGR gene uses separate promoters and translational start sites to produce 2 isoforms, PRA and PRB, which are identical except for an additional 165 amino acids present only in the N terminus of PRB. It can be observed in human breast tissues. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]
Uniprot Description
PR: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.
Protein type: Nuclear receptor; DNA-binding
Chromosomal Location of Human Ortholog: 11q22-q23
Cellular Component: nucleoplasm; mitochondrial outer membrane
Molecular Function: ligand-dependent nuclear receptor activity; protein binding; enzyme binding; DNA binding; zinc ion binding; steroid hormone receptor activity; steroid binding; receptor binding
Biological Process: transcription initiation from RNA polymerase II promoter; progesterone receptor signaling pathway; cell-cell signaling; epithelial cell maturation; steroid hormone mediated signaling; gene expression; positive regulation of transcription from RNA polymerase II promoter; signal transduction; ovulation from ovarian follicle; regulation of epithelial cell proliferation
Disease: Progesterone Resistance
Research Articles on PGR
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Product Notes
The PGR pgr (Catalog #AAA177029) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Progesterone Receptor antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Progesterone Receptor can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the PGR pgr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Progesterone Receptor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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