Western Blot (WB)
(Anti- Profilin1 Picoband antibody, MBS178330, Western blottingAll lanes: Anti Profilin1 (MBS178330) at 0.5ug/mlLane 1: Rat Testis Tissue Lysate at 50ugLane 2: Mouse Testis Tissue Lysate at 50ugLane 3: Human Placenta Tissue Lysate at 50ugLane 4: PANC Whole Cell Lysate at 40ugLane 5: SW620 Whole Cell Lysate at 40ugPredicted bind size: 15KDObserved bind size: 15KD )
Profilin 1 Polyclonal Antibody | anti-PFN1 antibody
Anti-Profilin 1 Antibody
Western Blot (WB)
(Anti- Profilin1 Picoband antibody, MBS178330, Western blottingAll lanes: Anti Profilin1 (MBS178330) at 0.5ug/mlLane 1: Rat Testis Tissue Lysate at 50ugLane 2: Mouse Testis Tissue Lysate at 50ugLane 3: Human Placenta Tissue Lysate at 50ugLane 4: PANC Whole Cell Lysate at 40ugLane 5: SW620 Whole Cell Lysate at 40ugPredicted bind size: 15KDObserved bind size: 15KD )
Western Blot (WB)
(Anti- Profilin1 Picoband antibody, MBS178330, Western blottingAll lanes: Anti Profilin1 (MBS178330) at 0.5ug/mlLane 1: Rat Testis Tissue Lysate at 50ugLane 2: Mouse Testis Tissue Lysate at 50ugLane 3: Human Placenta Tissue Lysate at 50ugLane 4: PANC Whole Cell Lysate at 40ugLane 5: SW620 Whole Cell Lysate at 40ugPredicted bind size: 15KDObserved bind size: 15KD )
Background: Profilin-1 is a protein that in humans is encoded by the PFN1 gene. The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. PFN1 is mapped to 17p13.2. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. This gene is a 140-amino acid protein and major growth regulator of filamentous (F)-actin through its binding of monomeric (G)-actin. It is thought to regulate actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]
Uniprot Description
profilin 1: a ubiquitous actin monomer-binding protein belonging to the profilin family. At high concentrations, profilin 1 prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Deletion of this gene is associated with Miller-Dieker syndrome.
Protein type: Motility/polarity/chemotaxis; Actin-binding; Cytoskeletal
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component: cell cortex; cytoplasm; cytoskeleton; cytosol; focal adhesion; membrane; neuron projection; nucleus; synapse
Molecular Function: actin binding; actin monomer binding; adenyl-nucleotide exchange factor activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding; receptor binding; Rho GTPase binding
Biological Process: actin cytoskeleton organization and biogenesis; negative regulation of actin filament bundle formation; negative regulation of actin filament polymerization; negative regulation of stress fiber formation; neural tube closure; positive regulation of actin filament bundle formation; positive regulation of actin filament polymerization; positive regulation of ATPase activity; positive regulation of DNA metabolic process; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of viral transcription; protein stabilization; Wnt receptor signaling pathway, planar cell polarity pathway
Disease: Amyotrophic Lateral Sclerosis 18
Research Articles on PFN1
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Product Notes
The PFN1 pfn1 (Catalog #AAA178330) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-Profilin 1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Profilin 1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the PFN1 pfn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Profilin 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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