Rabbit anti-Human PRKRA Polyclonal Antibody | anti-PRKRA antibody

PRKRA Antibody, FITC conjugated

Cat. Num. AAA1493343

• Gene Names: PRKRA; RAX; PACT; DYT16; HSD14
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G Purified
• Synonyms: PRKRA; Polyclonal Antibody; PRKRA Antibody; FITC conjugated; Interferon-inducible double-stranded RNA-dependent protein kinase activator A; PACT; RAX; HSD-14; HSD14; PKR-associated protein X; PKR-associating protein X; Protein activator of the interferon-induced protein kinase; Protein kinase; interferon-inducible double-stranded RNA-dependent activator; anti-PRKRA antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 302

• Applicable Applications for anti-PRKRA antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: FITC
• Immunogen: Recombinant human Interferon-inducible double-stranded RNA-dependent protein kinase activator A protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18768 / sc-32010 / sc-292629
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-PRKRA antibody

Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 213417911
• NCBI GeneID: 8575
• NCBI Accession #: NP_001132989.1
• NCBI GenBank Nucleotide #: NM_001139517.1
• UniProt Accession #: O75569; Q53G24; Q6X7T5; Q8NDK4; A8K3I6
• Molecular Weight: 31,635 Da
• NCBI Official Full Name: interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 2
• NCBI Official Synonym Full Names: protein activator of interferon induced protein kinase EIF2AK2
• NCBI Official Symbol: PRKRA
• NCBI Official Synonym Symbols: RAX; PACT; DYT16; HSD14
• NCBI Protein Information: interferon-inducible double-stranded RNA-dependent protein kinase activator A
• UniProt Protein Name: Interferon-inducible double-stranded RNA-dependent protein kinase activator A
• Protein Family: Interferon-inducible double-stranded RNA-dependent protein kinase activator
• UniProt Gene Name: PRKRA
• UniProt Synonym Gene Names: PACT; RAX
• UniProt Entry Name: PRKRA_HUMAN

NCBI Description

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Uniprot Description

PACT: a double strand RNA binding protein (dsRBP). Interacts with TRBP and Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA. Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. Activates the interferon-induced protein kinase PKR. Three alternatively spliced human isoforms have been reported.

Protein type: Activator; RNA processing; RNA-binding

Chromosomal Location of Human Ortholog: 2q31.2

Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; perinuclear region of cytoplasm

Molecular Function: double-stranded RNA binding; enzyme activator activity; enzyme binding; identical protein binding; protein binding; protein homodimerization activity

Biological Process: gene expression; immune response; middle ear morphogenesis; miRNA-mediated gene silencing, production of miRNAs; negative regulation of cell proliferation; outer ear morphogenesis; positive regulation of catalytic activity; pre-microRNA processing; protein amino acid phosphorylation; response to virus; RNA interference, production of siRNA; RNA-mediated gene silencing; skeletal morphogenesis

Disease: Dystonia 16