Rabbit anti-Human, Rat PPY Polyclonal Antibody | anti-PPY antibody

PPY Polyclonal Antibody

Cat. Num. AAA2560034

• Gene Names: PPY; PP; PNP
• Reactivity: Human, Rat
• Applications: Western Blot, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: PPY; Polyclonal Antibody; PPY Polyclonal Antibody; Pancreatic polypeptide; Pancreatic polypeptide Y; Pancreatic prohormone; PNP; PP; Prepro-PP (prepropancreatic polypeptide); anti-PPY antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 3mg/mL (varies by lot)
• Sequence Length: 95

• Applicable Applications for anti-PPY antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:1000-1:5000; ELISA: 1:5000-1:10000
• Immunogen: Synthetic peptide of human PPY
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of Rat pancreas tissue lysate using PPY Polyclonal Antibody at dilution of 1:2500)

Related Product Information for anti-PPY antibody

This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Product Categories/Family for anti-PPY antibody

Cancer; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 119572034
• NCBI GeneID: 5539
• UniProt Accession #: P01298
• Molecular Weight: 11 kDa
• NCBI Official Full Name: pancreatic polypeptide
• NCBI Official Synonym Full Names: pancreatic polypeptide
• NCBI Official Symbol: PPY
• NCBI Official Synonym Symbols: PP; PNP
• NCBI Protein Information: pancreatic prohormone
• UniProt Protein Name: Pancreatic prohormone
• Protein Family: Pancreatic hormone
• UniProt Gene Name: PPY
• UniProt Synonym Gene Names: PNP; PP; PH; PI
• UniProt Entry Name: PAHO_HUMAN

NCBI Description

This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

Uniprot Description

PPY: Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. Belongs to the NPY family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: extracellular space; extracellular region

Molecular Function: neuropeptide hormone activity; G-protein-coupled receptor binding; hormone activity; receptor binding

Biological Process: cell-cell signaling; neuropeptide signaling pathway; regulation of appetite; digestion; protein secretion; feeding behavior