Rabbit anti-Human PPP6C Polyclonal Antibody | anti-PPP6C antibody

PPP6C, CT (PPP6C, PPP6, Serine/threonine-protein phosphatase 6 catalytic subunit) (PE)

Cat. Num. AAA6336763

• Gene Names: PPP6C; PP6; PP6C
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PPP6C; Polyclonal Antibody; CT (PPP6C; PPP6; Serine/threonine-protein phosphatase 6 catalytic subunit) (PE); Serine/threonine-protein phosphatase 6 catalytic subunit; anti-PPP6C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
• Sequence Length: 283

• Applicable Applications for anti-PPP6C antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: PPP6C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-293 amino acids from the C-terminal region of human PPP6C.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(PPP6C Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the PPP6C antibody detected the PPP6C protein (arrow).)

Related Product Information for anti-PPP6C antibody

This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X.

Product Categories/Family for anti-PPP6C antibody

Antibodies; Enzymes; Phosphatase

References

Douglas, P., et al. Mol. Cell. Biol. 30(6):1368-1381(2010). Dema, B., et al. Genes Immun. 10(7):659-661(2009). Morales-Johansson, H., et al. PLoS ONE 4 (7), E6331 (2009): Mi, J., et al. PLoS ONE 4 (2), E4395 (2009): Stefansson, B., et al. Biochemistry 47(5):1442-1451(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 183603931
• NCBI GeneID: 5537
• NCBI Accession #: NP_001116841.1; NP_002712.1
• NCBI GenBank Nucleotide #: NP_001116841.1
• UniProt Accession #: O00743
• NCBI Official Full Name: serine/threonine-protein phosphatase 6 catalytic subunit isoform c
• NCBI Official Synonym Full Names: protein phosphatase 6 catalytic subunit
• NCBI Official Symbol: PPP6C
• NCBI Official Synonym Symbols: PP6; PP6C
• NCBI Protein Information: serine/threonine-protein phosphatase 6 catalytic subunit
• UniProt Protein Name: Serine/threonine-protein phosphatase 6 catalytic subunit
• Protein Family: Serine/threonine-protein phosphatase
• UniProt Gene Name: PPP6C
• UniProt Synonym Gene Names: PPP6; PP6C
• UniProt Entry Name: PPP6_HUMAN

NCBI Description

This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X. [provided by RefSeq, Jul 2008]

Uniprot Description

PPP6C: a Ser/Thr phosphatase. A functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: cytosol

Molecular Function: protein binding; metal ion binding; protein serine/threonine phosphatase activity

Biological Process: protein amino acid dephosphorylation; G1/S transition of mitotic cell cycle