Rabbit PPP2R3C Polyclonal Antibody | anti-PPP2R3C antibody

PPP2R3C Rabbit Polyclonal

Cat. Num. AAA7602954

• Gene Names: PPP2R3C; G4-1; G5pr; C14orf10
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PPP2R3C; Polyclonal Antibody; PPP2R3C Rabbit Polyclonal; anti-PPP2R3C antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 343

• Applicable Applications for anti-PPP2R3C antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Protein phosphatase 2 (formerly 2A), regulatory subunit B'', gamma
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain tissue slide using MBS7602954 (PPP2R3C Antibody) at dilution of 1:50)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7602954 (PPP2R3C Antibody) at dilution of 1:600)

NCBI and Uniprot Product Information

• NCBI GI #: 39645832
• NCBI GeneID: 55012
• Molecular Weight: 39,806 Da
• NCBI Official Full Name: PPP2R3C protein
• NCBI Official Synonym Full Names: protein phosphatase 2 regulatory subunit B''gamma
• NCBI Official Symbol: PPP2R3C
• NCBI Official Synonym Symbols: G4-1; G5pr; C14orf10
• NCBI Protein Information: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
• UniProt Protein Name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
• Protein Family: Serine/threonine-protein phosphatase
• UniProt Gene Name: PPP2R3C
• UniProt Synonym Gene Names: C14orf10; G5PR
• UniProt Entry Name: P2R3C_HUMAN

NCBI Description

This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Description

PPP2R3C: May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 14q13.2

Cellular Component: centrosome; cytoplasm; nucleus; spindle

Molecular Function: metal ion binding; protein binding

Biological Process: activation of protein kinase activity; B cell homeostasis; cortical cytoskeleton organization and biogenesis; microtubule cytoskeleton organization and biogenesis; positive regulation of B cell differentiation; regulation of antimicrobial humoral response; regulation of mitochondrial depolarization; spleen development; T cell homeostasis