Rabbit anti-Human PPP1R3C Polyclonal Antibody | anti-PPP1R3C antibody

PPP1R3C (PPP1R5, Protein Phosphatase 1 Regulatory Subunit 3C, Protein Phosphatase 1 Regulatory Subunit 5, Protein Targeting to Glycogen) (FITC)

Cat. Num. AAA6390431

• Gene Names: PPP1R3C; PPP1R5
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PPP1R3C; Polyclonal Antibody; PPP1R3C (PPP1R5; Protein Phosphatase 1 Regulatory Subunit 3C; Protein Phosphatase 1 Regulatory Subunit 5; Protein Targeting to Glycogen) (FITC); anti-PPP1R3C antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PPP1R3C.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-PPP1R3C antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human PPP1R3C, aa1-317 (NP_005389.1).
• Immunogen Sequence: MSCTRMIQVLDPRPLTSSVMPVDVAMRLCLAHSPPVKSFLGPYDEFQRRHFVNKLKPLKSCLNIKHKAKSQNDWKCSHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSALKHHEEKNLILDFPQPSTDYLSFRSHFQKNFVCLENCSLQERTVTGTVKVKNVSFEKKVQIRITFDSWKNYTDVDCVYMKNVYGGTDSDTFSFAIDLPPVIPTEQKIEFCISYHANGQVFWDNNDGQNYRIVHVQWKPDGVQTQMAPQDCAFHQTSPKTELESTIFGSPRLASGLFPEWQSWGRMENLASYR
• Conjugate: FITC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(PPP1R3C rabbit polyclonal antibody. Western Blot analysis of PPP1R3C expression in human liver.)

Western Blot (WB)

(Western Blot analysis of PPP1R3C expression in transfected 293T cell line by PPP1R3C polyclonal antibody. Lane 1: PPP1R3C transfected lysate (36.4kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-PPP1R3C antibody

Protein phosphatase-1 (PP1; see MIM 176875) participates in the regulation of a wide variety of cellular functions by reversible protein phosphorylation. The ability of PP1 to regulate diverse functions resides in its capacity to interact with a variety of regulatory subunits that may target PP1 to specific subcellular locations, modulate its substrate specificity, and allow its activity to be responsive to extracellular signals. Several targeting subunits of PP1 have been identified, including PPP1R5, the glycogen-binding subunits PPP1R3 (MIM 600917) and PPP1R4, and the nuclear inhibitor of PP1 (PPP1R8; MIM 602636).

Product Categories/Family for anti-PPP1R3C antibody

Antibodies; Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 4885559
• NCBI GeneID: 5507
• NCBI Accession #: NP_005389.1
• NCBI GenBank Nucleotide #: NM_005398.3
• UniProt Accession #: Q9UQK1; O95686; B2R7X0
• Molecular Weight: 36,445 Da
• NCBI Official Full Name: protein phosphatase 1 regulatory subunit 3C
• NCBI Official Synonym Full Names: protein phosphatase 1, regulatory subunit 3C
• NCBI Official Symbol: PPP1R3C
• NCBI Official Synonym Symbols: PPP1R5
• NCBI Protein Information: protein phosphatase 1 regulatory subunit 3C; PTG; PP1 subunit R5; protein targeting to glycogen; protein phosphatase 1 regulatory subunit 5; Phosphatase 1, regulatory inhibitor subunit 5; protein phosphatase 1, regulatory (inhibitor) subunit 3C
• UniProt Protein Name: Protein phosphatase 1 regulatory subunit 3C
• Protein Family: Protein phosphatase 1 regulatory
• UniProt Gene Name: PPP1R3C
• UniProt Synonym Gene Names: PPP1R5; PP1 subunit R5; PTG
• UniProt Entry Name: PPR3C_HUMAN

NCBI Description

This gene encodes a regulatory subunit of protein phosphatase-1 (PP1). PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities: neuronal, muscular, RNA splicing, protein synthesis, cell death, and glycogen metabolism, to name just a few. By interacting with different regulatory subunits, PP1 is directed to different parts of the cell, to different substrates, or to respond to extracellular signals. [provided by RefSeq, Oct 2011]

Uniprot Description

PPP1R3C: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.

Protein type: Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q23-q24

Cellular Component: cytosol

Molecular Function: protein binding; protein serine/threonine phosphatase activity; protein phosphatase binding

Biological Process: glycogen biosynthetic process; dephosphorylation; carbohydrate metabolic process; glucose metabolic process; pathogenesis