Rabbit PPP1CC Polyclonal Antibody | anti-PPP1CC antibody

PPP1CC Rabbit Polyclonal

Cat. Num. AAA7602929

• Gene Names: PPP1CC; PP1C; PP-1G; PPP1G
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PPP1CC; Polyclonal Antibody; PPP1CC Rabbit Polyclonal; anti-PPP1CC antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 330

• Applicable Applications for anti-PPP1CC antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Protein phosphatase 1, catalytic subunit, gamma isoform
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human gastric cancer using MBS7602929 (PPP1CC antibody) at dilution of 1:100)

Western Blot (WB)

(MCF7 cells were subjected to SDS PAGE followed by western blot with MBS7602929 (PPP1CC antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 767974684
• NCBI GeneID: 5501
• NCBI Accession #: XP_011536807.1
• NCBI GenBank Nucleotide #: XM_011538505.2
• Molecular Weight: 38,518 Da
• NCBI Official Full Name: serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X2
• NCBI Official Synonym Full Names: protein phosphatase 1 catalytic subunit gamma
• NCBI Official Symbol: PPP1CC
• NCBI Official Synonym Symbols: PP1C; PP-1G; PPP1G
• NCBI Protein Information: serine/threonine-protein phosphatase PP1-gamma catalytic subunit
• UniProt Protein Name: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
• Protein Family: Serine/threonine-protein phosphatase
• UniProt Gene Name: PPP1CC
• UniProt Synonym Gene Names: PP-1G
• UniProt Entry Name: PP1G_HUMAN

NCBI Description

The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

PPP1CC: is a catalytic subunit of protein phosphatase 1 (PP1), a ubiquitous cytosolic serine-threonine phosphatase. Composed a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting (or regulatory) subunits: PPP1R12A and PPP1R12B mediate binding to myosin; PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen; and PPP1R15A and PPP1R15B mediate binding to EIF2S1. PP1 is essential for cell division, plays critical roles in many cellular processes including glycogen metabolism, muscle contractility and protein synthesis, and is involved in the regulation of ionic conductances and long-term synaptic plasticity. Inhibits the synthesis of proteins involved in synaptic plasticity. Binds to the transcription factor cyclic AMP-dependent response element binding (CREB) and dephosphorylates it. May regulate chromatin condensation through regulation of histone H3 phosphorylation. Differentially expressed in gastric cancer. May participate in the neurodegenerative progress in Alzheimer's disease. Down-regulated in lung squamous cell carcinoma.

Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Nucleolus; Protein phosphatase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 12q24.1-q24.2

Cellular Component: cleavage furrow; cytoplasm; cytosol; dendritic spine; focal adhesion; midbody; mitochondrial outer membrane; mitochondrion; nuclear chromosome, telomeric region; nuclear speck; nucleolus; nucleus; protein complex

Molecular Function: lamin binding; metal ion binding; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein binding; protein C-terminus binding; protein complex binding; protein domain specific binding; protein kinase binding; protein N-terminus binding; protein phosphatase 1 binding; protein serine/threonine phosphatase activity

Biological Process: cell division; circadian regulation of gene expression; entrainment of circadian clock by photoperiod; glycogen metabolic process; neuron differentiation; protein amino acid dephosphorylation; regulation of circadian rhythm; regulation of nucleocytoplasmic transport; sister chromatid cohesion