Rabbit PPM1L Polyclonal Antibody | anti-PPM1L antibody

PPM1L Rabbit Polyclonal

Cat. Num. AAA7602922

• Gene Names: PPM1L; PP2CE; PPM1-LIKE; PP2C-epsilon
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PPM1L; Polyclonal Antibody; PPM1L Rabbit Polyclonal; anti-PPM1L antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 233

• Applicable Applications for anti-PPM1L antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Protein phosphatase 1 (formerly 2C)-like
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney tissue slide using MBS7602922 (PPM1L Antibody) at dilution of 1:50)

Western Blot (WB)

(mouse kidney tissue were subjected to SDS PAGE followed by western blot with MBS7602922 (PPM1L antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 961658084
• NCBI GeneID: 151742
• NCBI Accession #: NP_001304840.1
• NCBI GenBank Nucleotide #: NM_001317911.1
• Molecular Weight: 22,475 Da
• NCBI Official Full Name: protein phosphatase 1L isoform 2
• NCBI Official Synonym Full Names: protein phosphatase, Mg2+/Mn2+ dependent 1L
• NCBI Official Symbol: PPM1L
• NCBI Official Synonym Symbols: PP2CE; PPM1-LIKE; PP2C-epsilon
• NCBI Protein Information: protein phosphatase 1L
• UniProt Protein Name: Protein phosphatase 1L
• Protein Family: Protein phosphatase
• UniProt Gene Name: PPM1L
• UniProt Synonym Gene Names: PP2CE; PP2C-epsilon
• UniProt Entry Name: PPM1L_HUMAN

NCBI Description

The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Description

PPM1L: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor); Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q26.1

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: metal ion binding; protein serine/threonine phosphatase activity

Biological Process: MAPKKK cascade; protein amino acid dephosphorylation; sphingolipid biosynthetic process; transmembrane receptor protein serine/threonine kinase signaling pathway