Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PPARGC1B Polyclonal Antibody at dilution 1:40)
Rabbit PPARGC1B Polyclonal Antibody | anti-PPARGC1B antibody
PPARGC1B Polyclonal Antibody
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PPARGC1B Polyclonal Antibody at dilution 1:40)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PPARGC1B Polyclonal Antibody at dilution 1:40)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PPARGC1B Polyclonal Antibody at dilution 1:40)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PPARGC1B Polyclonal Antibody at dilution 1:40)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Uniprot Description
PGC-1 beta: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: nucleoplasm; mitochondrion; Srb-mediator complex; nucleus
Molecular Function: ligand-dependent nuclear receptor transcription coactivator activity; AF-2 domain binding; RNA binding; nucleotide binding; estrogen receptor binding; transcription factor binding; receptor activator activity
Biological Process: transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; ossification; estrogen receptor signaling pathway; response to cAMP; positive regulation of osteoclast differentiation; organelle organization and biogenesis; response to glucocorticoid stimulus; actin filament organization; cellular lipid metabolic process; transcription from mitochondrial promoter; regulation of transcription, DNA-dependent; positive regulation of bone resorption; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of phosphorylation
Disease: Obesity
Research Articles on PPARGC1B
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Product Notes
The PPARGC1B ppargc1b (Catalog #AAA2518064) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PPARGC1B Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PPARGC1B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). IHC: 1:25-1:100. Researchers should empirically determine the suitability of the PPARGC1B ppargc1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPARGC1B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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