Rabbit PPAR DELTA Polyclonal Antibody | anti-PPAR DELTA antibody

RABBIT ANTI PPAR DELTA (N-TERMINAL)

Cat. Num. AAA221543

• Gene Names: Ppard; NUC1; NUC-1; Nr1c2; Pparb; PPAR[b]; Pparb/d; PPAR-beta; PPARdelta; PPAR-delta
• Reactivity: Chimpanzee (Expected from Sequence), Mouse (Expected from Sequence), Rabbit (Expected from Sequence), Rat (Expected from Sequence)
• Applications: ELISA, Western Blot
• Synonyms: PPAR DELTA; Polyclonal Antibody; RABBIT ANTI PPAR DELTA (N-TERMINAL); anti-PPAR DELTA antibody

• Host: Rabbit
• Reactivity: Chimpanzee (Expected from Sequence), Mouse (Expected from Sequence), Rabbit (Expected from Sequence), Rat (Expected from Sequence)
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This item detects peroxisome proliferator-activated receptor, delta (PPARD), a member of the nuclear hormone receptor subfamily. Upon activation, PPARD forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARD controls genes involved in lipid metabolism, and enhances fatty acid catabolism and energy uncoupling in adipose tissue and skeletal muscle. ; ; PPARD has also been implicated in the proliferation and differentiation of preadipocytes, enterocytes, keratinocytes and the placenta. ; ; PPARD agonists could be used therapeutically to target multiple components of the metabolic syndrome, including insulin resistance, hyperglycemia, dyslipidemia, and atherosclerosis.
• Form/Format: Purified; Purified IgG - liquid
• Concentration: IgG concentration 1.0 mg/ml (varies by lot)
• Sequence Length: 440

• Applicable Applications for anti-PPAR DELTA antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: Western Blot: This item detects a band of approximately 55kDa in heart whole cell lysates.; ELISA: Minimum Dilution: 1/2000; Maximum Dilution: 1/8000; Western Blotting: Minimum Dilution: 1/500; Maximum Dilution: 1/2000
• Perservative Stabilisers: 0.09% Sodium Azide (NaN3)
• Immunogen: Syntetic peptide corresponding to amino acids 1-14 of mouse PPAR delta.; Buffer Solution
• Antiserum Preparation: Antisera to PPAR delta were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography.
• Target Species: Human
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Related Product Information for anti-PPAR DELTA antibody

MBS221543 detects peroxisome proliferator-activated receptor, delta (PPARD), a member of the nuclear hormone receptor subfamily. Upon activation, PPARD forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARD controls genes involved in lipid metabolism, and enhances fatty acid catabolism and energy uncoupling in adipose tissue and skeletal muscle. PPARD has also been implicated in the proliferation and differentiation of preadipocytes, enterocytes, keratinocytes and the placenta. PPARD agonists could be used therapeutically to target multiple components of the metabolic syndrome, including insulin resistance, hyperglycemia, dyslipidemia, and atherosclerosis.

NCBI and Uniprot Product Information

• NCBI GI #: 33859590
• NCBI GeneID: 19015
• NCBI Accession #: NP_035275.1
• NCBI GenBank Nucleotide #: NM_011145.3
• UniProt Accession #: P35396; P37239
• Molecular Weight: 49,715 Da
• NCBI Official Full Name: peroxisome proliferator-activated receptor delta
• NCBI Official Synonym Full Names: peroxisome proliferator activator receptor delta
• NCBI Official Symbol: Ppard
• NCBI Official Synonym Symbols: NUC1; NUC-1; Nr1c2; Pparb; PPAR[b]; Pparb/d; PPAR-beta; PPARdelta; PPAR-delta
• NCBI Protein Information: peroxisome proliferator-activated receptor delta; PPARdelta/beta; Peroxisome proliferator-activated receptor beta; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2
• UniProt Protein Name: Peroxisome proliferator-activated receptor delta
• UniProt Gene Name: Ppard
• UniProt Synonym Gene Names: Nr1c2; Pparb; PPAR-delta; NUC1; PPAR-beta
• UniProt Entry Name: PPARD_MOUSE

Uniprot Description

PPAR-delta: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Belongs to the nuclear hormone receptor family. NR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor; DNA-binding

Cellular Component: nucleus

Molecular Function: ligand-dependent nuclear receptor activity; zinc ion binding; prostacyclin receptor activity; metal ion binding; transcription coactivator activity; enzyme activator activity; drug binding; retinoid X receptor binding; NF-kappaB binding; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; steroid hormone receptor activity; transcription factor activity; lipid binding; fatty acid binding

Biological Process: positive regulation of catalytic activity; transcription from RNA polymerase II promoter; proteoglycan metabolic process; epidermis development; wound healing; regulation of fat cell differentiation; negative regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; negative regulation of collagen biosynthetic process; positive regulation of epidermis development; negative regulation of smooth muscle cell migration; negative regulation of transcription from RNA polymerase II promoter; positive regulation of vasodilation; vitamin A metabolic process; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; axon ensheathment; cell differentiation; negative regulation of epithelial cell proliferation; placenta development; intracellular receptor-mediated signaling pathway; transcription, DNA-dependent; positive regulation of insulin secretion; keratinocyte proliferation; cell-substrate adhesion; keratinocyte migration; regulation of cell proliferation; phospholipid biosynthetic process; positive regulation of phosphoinositide 3-kinase cascade; regulation of transcription from RNA polymerase II promoter; cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of inflammatory response; mRNA transcription; steroid hormone mediated signaling; fatty acid oxidation; lipid metabolic process; negative regulation of cell growth; anagen; regulation of insulin secretion; cellular process; embryo implantation; negative regulation of apoptosis