Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MBS7129546(POU6F2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200))
Rabbit POU6F2 Polyclonal Antibody | anti-POU6F2 antibody
POU6F2 Antibody
WB: 1:200-1:1000
IHC: 1:50-1:200
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MBS7129546(POU6F2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200))
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using MBS7129546(POU6F2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200))
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using MBS7129546(POU6F2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200))
Immunohistochemistry (IHC)-Paraffin
(The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using MBS7129546(POU6F2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200))
SDS-Page
(Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane: Mouse heart tissue, Primary antibody: MBS7129546(POU6F2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds)
SDS-Page
(Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane: Mouse heart tissue, Primary antibody: MBS7129546(POU6F2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Uniprot Description
Function: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.
Subcellular location: Nucleus
Probable.
Tissue specificity: Expressed only within the CNS, where its expression is restricted to the medical habenulla, to a dispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in the retina. Ref.1
Involvement in disease: Hereditary susceptibility to Wilms tumor 5 (WT5) [MIM:601583]: Pediatric malignancy of kidney and one of the most common solid cancers in childhood.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4
Sequence similarities: Belongs to the POU transcription factor family. Class-6 subfamily.Contains 1 homeobox DNA-binding domain.Contains 1 POU-specific domain.
Sequence caution: The sequence AAB49727.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAB49728.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAS07475.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence EAL23992.1 differs from that shown. Reason: Erroneous gene model prediction.
Research Articles on POU6F2
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Product Notes
The POU6F2 pou6f2 (Catalog #AAA7129546) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The POU6F2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's POU6F2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). ELISA: 1:1000-1:2000 WB: 1:200-1:1000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the POU6F2 pou6f2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "POU6F2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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