Rabbit anti-Mouse POF1B Polyclonal Antibody | anti-POF1B antibody

POF1B, ID (POF1B, Protein POF1B, Premature ovarian failure protein 1B) (FITC)

Cat. Num. AAA6335513

• Gene Names: POF1B; POF; POF2B
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: POF1B; Polyclonal Antibody; ID (POF1B; Protein POF1B; Premature ovarian failure protein 1B) (FITC); Premature ovarian failure protein 1B; anti-POF1B antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-POF1B antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: POF1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-366 amino acids from the Central region of human POF1B.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(POF1B Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the POF1B antibody detected the POF1B protein (arrow).)

Related Product Information for anti-POF1B antibody

Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called 'POF1' and 'POF2' have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined.

Product Categories/Family for anti-POF1B antibody

Antibodies; Proteins

References

Rizzolio, F., et al. Gene Expr. Patterns 7(4):529-534(2007). Lacombe, A., et al. Am. J. Hum. Genet. 79(1):113-119(2006). Bione, S., et al. Hum. Reprod. 19(12):2759-2766(2004). Bione, S., et al. Semin. Reprod. Med. 18(1):51-57(2000). Riva, P., et al. Clin. Genet. 50(4):267-269(1996).

NCBI and Uniprot Product Information

• NCBI GI #: 193794853
• NCBI GeneID: 79983
• NCBI Accession #: NP_079197.3
• NCBI GenBank Nucleotide #: NM_024921.3
• UniProt Accession #: Q8WVV4; Q5H9E9; Q5H9F0; Q8NG12; Q9H5Y2; Q9H738; Q9H744; A8K2U5
• Molecular Weight: 34,841 Da
• NCBI Official Full Name: protein POF1B
• NCBI Official Synonym Full Names: premature ovarian failure, 1B
• NCBI Official Symbol: POF1B
• NCBI Official Synonym Symbols: POF; POF2B
• NCBI Protein Information: protein POF1B; premature ovarian failure protein 1B
• UniProt Protein Name: Protein POF1B
• Protein Family: Protein
• UniProt Gene Name: POF1B
• UniProt Entry Name: POF1B_HUMAN

NCBI Description

Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called "POF1" and "POF2" have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined. [provided by RefSeq, Jan 2010]