Western Blot (WB)
(Western blot analysis of lysates from A549,Jurkat cell line (from left to right),using PNPLA8 Antibody(MBS9201360). MBS9201360 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.)
Rabbit anti-Human, mouse PNPLA8 Polyclonal Antibody | anti-PNPLA8 antibody
PNPLA8 Antibody
Western Blot (WB)
(Western blot analysis of lysates from A549,Jurkat cell line (from left to right),using PNPLA8 Antibody(MBS9201360). MBS9201360 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.)
Western Blot (WB)
(Western blot analysis of lysates from A549,Jurkat cell line (from left to right),using PNPLA8 Antibody(MBS9201360). MBS9201360 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysates at 35ug per lane.)
Mancuso D.J.,et al.J. Biol. Chem. 275:9937-9945(2000).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Hillier L.W.,et al.Nature 424:157-164(2003).
Scherer S.W.,et al.Science 300:767-772(2003).
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the patatin-like phospholipase domain containing protein family. Members of this family are phospholipases which catalyze the cleavage of fatty acids from membrane phospholipids. The product of this gene is a calcium-independent phospholipase. Mutations in this gene have been associated with mitochondrial myopathy with lactic acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2015]
Uniprot Description
PNPLA8: Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; EC 3.1.1.5; Membrane protein, integral; Phospholipase
Chromosomal Location of Human Ortholog: 7q31
Cellular Component: Golgi membrane; peroxisomal membrane; endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; integral to membrane; peroxisome; intracellular
Molecular Function: calcium-independent phospholipase A2 activity; ATP binding; lysophospholipase activity
Biological Process: cell death; phosphatidylethanolamine catabolic process; phospholipid metabolic process; glycerophospholipid biosynthetic process; linoleic acid metabolic process; arachidonic acid metabolic process; fatty acid metabolic process; prostaglandin biosynthetic process; arachidonic acid secretion
Disease: Mitochondrial Myopathy With Lactic Acidosis
Research Articles on PNPLA8
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Product Notes
The PNPLA8 pnpla8 (Catalog #AAA9201360) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 708-732. The PNPLA8 Antibody reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PNPLA8 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~ 1:1000. Researchers should empirically determine the suitability of the PNPLA8 pnpla8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PNPLA8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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