Western Blot (WB)
(Western Blot analysis of PNMA1 expression in transfected 293T cell line by PNMA1 polyclonal antibody. Lane 1: PNMA1 transfected lysate (39.8kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human PNMA1 Polyclonal Antibody | anti-PNMA1 antibody
PNMA1 (Paraneoplastic Antigen Ma1, 37kD Neuronal Protein, Neuron-and Testis-specific Protein 1, MA1) (Biotin)
Western Blot (WB)
(Western Blot analysis of PNMA1 expression in transfected 293T cell line by PNMA1 polyclonal antibody. Lane 1: PNMA1 transfected lysate (39.8kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of PNMA1 expression in transfected 293T cell line by PNMA1 polyclonal antibody. Lane 1: PNMA1 transfected lysate (39.8kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
The PNMA1 gene encodes an antineuronal antibody (anti-Ma) present in patients with paraneoplastic neurologic disorders (Dalmau et al., 1999 [PubMed 10050892]). Some paraneoplastic syndromes affecting the nervous system are associated with antibodies that react with neuronal proteins and the causal tumor (onconeuronal antigens) (summarized by Dalmau et al., 1999 [PubMed 10050892]). Several of these antibodies are markers of specific neurologic syndromes associated with distinct types of cancer. The presence of some antibodies is so specific that disorders previously identified by brain biopsy or at autopsy can be diagnosed serologically. The expression of neuronal proteins by the tumor appears to be a crucial step that breaks the immune tolerance for otherwise normal neuronal proteins. The identity of most onconeuronal antigens was established by probing human cDNA expression libraries with serum containing antineuronal antibodies.[supplied by OMIM, May 2010]
Uniprot Description
PNMA1: Belongs to the PNMA family
Protein type: Nucleolus
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: focal adhesion; cytoplasm; nucleolus
Molecular Function: protein binding
Biological Process: inflammatory response to antigenic stimulus; positive regulation of apoptosis
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Product Notes
The PNMA1 pnma1 (Catalog #AAA6389968) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PNMA1 (Paraneoplastic Antigen Ma1, 37kD Neuronal Protein, Neuron-and Testis-specific Protein 1, MA1) (Biotin) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PNMA1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the PNMA1 pnma1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PNMA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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