Immunohistochemistry (IHC)
(Immunochemical staining of human PNKD in human stomach with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human PNKD Polyclonal Antibody | anti-PNKD antibody
Anti-PNKD Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
PNKD; Polyclonal Antibody; Anti-PNKD Antibody; Rabbit Polyclonal; PNKD Antibody; Rabbit PAb; Antigen Affinity Purified; paroxysmal nonkinesigenic dyskinesia; Anti-BRP17 Antibody; Anti-DYT8 Antibody; Anti-FKSG19 Antibody; Anti-FPD1 Antibody; Anti-KIPP1184 Antibody; Anti-MR-1 Antibody; Anti-MR1 Antibody; Anti-PDC Antibody; Anti-PKND1 Antibody; Anti-TAHCCP2 Antibody; anti-PNKD antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human PNKD
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-PNKD antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:100-1:500
Immunogen
E Coli-derived Human PNKD fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human PNKD fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human PNKD in human stomach with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human PNKD in human stomach with rabbit polyclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-PNKD antibody
Paroxysmal nonkinesigenic dyskinesia (PNKD) is a rare movement disorder characterized by sudden attacks of involuntary movements. Familial PNKD is an autosomal dominant trait, caused by mutations in the myofibrillogenesis regulator 1 (MR-1) gene on chromosome 2q35. Myofibrillogenesis regulator-1 (MR-1), the gene responsible for PNKD, is transcribed into three alternatively spliced forms: long (MR-1L), medium (MR-1M), and small (MR-1S). PNKD is triggered by stress, fatigue, menstruation, or consumption of either alcohol or caffeine. Attacks last 1-4 h and consist of dramatic dystonia and choreoathetosis in the limbs, trunk, and face. The clinical features and genetic findings of PNKD, rarely described in the Asians, were mostly delineated from European families.
References
Wang J, et al. (2018) Myofibrillogenesis regulator 1 (mr-1): A potential therapeutic target for cancer and pnkd. J Drug Target 26 (8): 643-648.Shen Y, et al. (2011) Mutations in pnkd causing paroxysmal dyskinesia alters protein cleavage and stability. Hum Mol Genet 20 (12): 2322-2332.Ghezzi D, et al. (2015) A family with paroxysmal nonkinesigenic dyskinesias (pnkd): Evidence of mitochondrial dysfunction. Eur J Paediatr Neurol 19 (1): 64-68.Ghezzi D, et al. (2009) Paroxysmal non-kinesigenic dyskinesia is caused by mutations of the mr-1 mitochondrial targeting sequence. Hum Mol Genet 18 (6): 1058-1064.
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Product Notes
The PNKD (Catalog #AAA8109274) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-PNKD Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PNKD can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:100-1:500. Researchers should empirically determine the suitability of the PNKD for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PNKD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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