Rabbit anti-Human PMP 22 Polyclonal Antibody | anti-PMP22 antibody
PMP 22 (Peripheral Myelin Protein) (APC)
Reactivity
Human
Applications
Immunohistochemistry
Purity
Purified by Immunoaffinity chromatography.
Synonyms
PMP 22; Polyclonal Antibody; PMP 22 (Peripheral Myelin Protein) (APC); anti-PMP22 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human PMP-22.
Purity/Purification
Purified by Immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Applicable Applications for anti-PMP22 antibody
Immunohistochemistry (IHC) Frozen/Paraffin
Application Notes
IHC-F/P: 1:12.5-1:25 for 60 min. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.
Applications are based on unconjugated antibody.
Applications are based on unconjugated antibody.
Immunogen
A synthetic peptide from near C-terminal of human PMP-22. Epitope: Near C-terminus. Cellular Localization: Cytoplasmic, Molecular Weight of Antigen: 22kD.
Conjugate
APC
Positive Control
Peripheral nerve, pancreatic islets.
Note
Preservative Free
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-PMP22 antibody
PMP-22 (Peripheral Myelin Protein) is a glycoprotein expressed in the compact myelin of the peripheral nervous system. In the peripheral nervous system, PMP-22 is produced by myelinating Schwann cells and is coexpressed with the genes for myelin basic protein (MBP) and protein P0 during nerve development and regeneration. However, Schwannoma cells not associated with peripheral nerve will be negative. Alterations in the level of this protein cause several genetic human diseases. If the protein is duplicated, patients develop Charcot-Marie-Tooth disease. If one copy of the gene is deleted, they suffer from the inherited tendency to pressure palsies. PMP-22 has recently been reported in high-grade osteosarcoma.
Product Categories/Family for anti-PMP22 antibody
References
1. J Cell Biol 117(1), 225-238 1992 2. Neurology 1997;48(2):445-449 3. Ann Neurol 1997;42(6):866-872 4. Neurosci 1997, 17(20):7754-62 1997 5. Brain (2000), 123, 1001-1006 6. Cancer Genet cytogenet 2004 152(2):113-8.
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Product Notes
The PMP22 (Catalog #AAA6494055) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PMP 22 (Peripheral Myelin Protein) (APC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PMP 22 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Frozen/Paraffin. IHC-F/P: 1:12.5-1:25 for 60 min. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min. Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the PMP22 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PMP 22, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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