Rabbit PLXNA2 Polyclonal Antibody | anti-PLXNA2 antibody

PLXNA2 Polyclonal Antibody

Cat. Num. AAA3006461

• Gene Names: PLXNA2; OCT; PLXN2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: PLXNA2; Polyclonal Antibody; PLXNA2 Polyclonal Antibody; Plexin-A2; Semaphorin receptor OCT; KIAA0463; OCT; PLXN2; UNQ209/PRO235; anti-PLXNA2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: PLXNA2 polyclonal antibody detects endogenous levels of PLXNA2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1894

• Applicable Applications for anti-PLXNA2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human PLXNA2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of PLXNA2 polyclonal antibody at 1:500 dilutionLane1:A549 whole cell lysateLane2:Raw264. 7 whole cell lysateLane3:PC12 whole cell lysate)

Related Product Information for anti-PLXNA2 antibody

Plexins are a family of large, transmembrane receptors for multiple classes of semaphorins in vertebrates. Plexins are widely expressed, and regions of their extracellular domain are homologus to both scatter factor receptors and semaphorin domains. Plexins may act as semaphorin receptors alone or in combination with neuropilins. Plexins are divided into four subfamilies designated plexin-A, -B, -C, and -D. Drosophila plexin-A is a receptor for class I semaphorins and controls motor and axon guidance. Plexin-A3 mediates cell-repelling cues. Plexins B and C are receptors for Sema 4 and Sema 7, respectively.

NCBI and Uniprot Product Information

• NCBI GI #: 113722116
• NCBI GeneID: 5362
• NCBI Accession #: NP_079455.3
• NCBI GenBank Nucleotide #: NP_079455.3
• UniProt Accession #: O75051
• Molecular Weight: ~ 237kDa
• NCBI Official Full Name: plexin-A2
• NCBI Official Synonym Full Names: plexin A2
• NCBI Official Symbol: PLXNA2
• NCBI Official Synonym Symbols: OCT; PLXN2
• NCBI Protein Information: plexin-A2
• UniProt Protein Name: Plexin-A2
• Protein Family: Plexin
• UniProt Gene Name: PLXNA2
• UniProt Synonym Gene Names: KIAA0463; OCT; PLXN2

NCBI Description

This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]

Uniprot Description

Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm ().