Goat anti-Mouse Plexin A3 Polyclonal Antibody | anti-PLXNA3 antibody
Plexin A3 (SEX)
Purified by mouse Plexin A3 affinity chromatography.
Purified by mouse Plexin A3 affinity chromatography.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the plexin class of proteins. The encoded protein is a transmembrane protein that is exposed on the cell surface. This gene is thought to be involved in epithelial and neural tissue development. [provided by RefSeq]
Uniprot Description
PLXNA3: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Interacts with CBFA2T3/MTG16. Belongs to the plexin family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq28
Cellular Component: membrane; integral to membrane; plasma membrane; intracellular
Molecular Function: protein binding; transmembrane receptor activity; semaphorin receptor activity
Biological Process: facial nerve structural organization; axon guidance; trigeminal nerve structural organization; branchiomotor neuron axon guidance; multicellular organismal development; hippocampus development; negative chemotaxis; positive regulation of cytoskeleton organization and biogenesis; pyramidal neuron development; negative regulation of axon extension involved in axon guidance
Research Articles on PLXNA3
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Product Notes
The PLXNA3 plxna3 (Catalog #AAA617828) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Plexin A3 (SEX) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Plexin A3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC). Western Blot: This antibody can be used at 0.1-0.2ug/ml with the appropriate secondary reagents to detect mouse Plexin A3. The detection limit for rmPlexin A3 is approximately 2 ng/lane under non-reducing and reducing conditions., Immunohistochemistry: This antibody has been used at a concentration of 10ug/ml to detect Plexin A3 in cryosections of E13 mouse embryos. Tissue was fixed overnight in 4%PFA+14%picric acid in PBS at 4 degree C. Sections were blocked with 10% donkey serum and 0.1% Triton in 1% BSA in PBS for 45 minutes at room temperature. After blocking, sections were incubated with primary antibody for 3 hours at room temperature followed by NorthernLightsTM 557 donkey anti-goat lgG at room temperature for 1 hour. Between each step, sections were washed with 0.1% BSA in PBS., Direct ELISA: This antibody can be used at 0.5-1.0ug/ml with the appropriate secondary reagents to detect mouse Plexin A3. The detection limit for rmPlexin A3 is approximately 1.0 ng/well., Optimal dilutions should be determined by each laboratory for each application. Researchers should empirically determine the suitability of the PLXNA3 plxna3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Plexin A3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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