Western Blot (WB)
(Anti-Pleiotrophin antibody, MBS175297, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Rat Kidney Tissue LysateLane 3: MCF-7 Cell LysateLane 4: HT1080 Cell LysateLane 5: SMMC Cell Lysate )
Rabbit Pleiotrophin Polyclonal Antibody | anti-PTN antibody
Anti-Pleiotrophin antibody
Gene Names
PTN; HARP; HBNF; HBGF8; NEGF1
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
Immunogen affinity purified.
Synonyms
Pleiotrophin; Polyclonal Antibody; Anti-Pleiotrophin antibody; Pleiotrophin(PTN); pleiotrophin; HARP antibody; HB-GAM antibody; HBBM antibody; HBGAM antibody; HBGF-8 antibody; HBGF8 antibody; HBNF antibody; HBNF-1 antibody; HBNF1 antibody; Heparin binding growth associated molecule antibody; Heparin binding growth factor 8 antibody; Heparin binding neurite outgrowth promoting factor 1 antibody; Heparin-binding brain mitogen antibody; Heparin-binding growth factor 8 antibody; Heparin-binding growth-associated molecule antibody; Heparin-binding neurite outgrowth-promoting factor 1 antibody; NEGF1 antibody; Neurite growth promoting factor 1 antibody; OSF-1 antibody; OSF1 antibody; Osteoblast-specific factor 1 antibody; Pleiotrophin antibody; PTN antibody; PTN_HUMAN antibody; anti-PTN antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
168
Applicable Applications for anti-PTN antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Pleiotrophin (150-168aa QAESKKKKKEGKKQEKMLD), identical to the related rat and mouse sequences.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Western Blot (WB)
(Anti-Pleiotrophin antibody, MBS175297, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Rat Kidney Tissue LysateLane 3: MCF-7 Cell LysateLane 4: HT1080 Cell LysateLane 5: SMMC Cell Lysate )
Western Blot (WB)
(Anti-Pleiotrophin antibody, MBS175297, Western blottingLane 1: Rat Brain Tissue LysateLane 2: Rat Kidney Tissue LysateLane 3: MCF-7 Cell LysateLane 4: HT1080 Cell LysateLane 5: SMMC Cell Lysate )
Immunohistochemistry (IHC)
(Anti-Pleiotrophin antibody, MBS175297, IHC(P)IHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-Pleiotrophin antibody, MBS175297, IHC(P)IHC(P): Human Mammary Cancer Tissue )
Related Product Information for anti-PTN antibody
Description: Rabbit IgG polyclonal antibody for Pleiotrophin(PTN) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: Pleiotrophin(PTN) also known as heparin-binding brain mitogen(HBBM) or heparin-binding growth factor 8(HBGF-8) or neurite growth-promoting factor 1(NEGF1) or heparin affinity regulatory peptide(HARP) or heparin binding growth associated molecule(HB-GAM) is a protein that in humans is encoded by the PTN gene. PTN is the first member of a family of developmentally regulated cytokines. The PTN gene is mapped to 7q33-q34. A mutant PTN that contained only the first N-terminal 40 amino acids was a dominant negative. Pleiotrophin is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. Pleiotrophin binds to cell-surface nucleolin as a low affinity receptor. This binding can inhibit HIV infection.
Background: Pleiotrophin(PTN) also known as heparin-binding brain mitogen(HBBM) or heparin-binding growth factor 8(HBGF-8) or neurite growth-promoting factor 1(NEGF1) or heparin affinity regulatory peptide(HARP) or heparin binding growth associated molecule(HB-GAM) is a protein that in humans is encoded by the PTN gene. PTN is the first member of a family of developmentally regulated cytokines. The PTN gene is mapped to 7q33-q34. A mutant PTN that contained only the first N-terminal 40 amino acids was a dominant negative. Pleiotrophin is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. Pleiotrophin binds to cell-surface nucleolin as a low affinity receptor. This binding can inhibit HIV infection.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
18,942 Da
NCBI Official Full Name
Pleiotrophin
NCBI Official Synonym Full Names
pleiotrophin
NCBI Official Symbol
PTN
NCBI Official Synonym Symbols
HARP; HBNF; HBGF8; NEGF1
NCBI Protein Information
pleiotrophin; HBBM; OSF-1; HB-GAM; HBGF-8; HBNF-1; osteoblast-specific factor 1; heparin-binding brain mitogen; heparin binding growth factor 8; heparin-binding growth factor 8; heparin affin regulatory protein; neurite growth-promoting factor 1; heparin-binding growth-associated molecule; heparin-binding neurite outgrowth-promoting factor 1; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
UniProt Protein Name
Pleiotrophin
Protein Family
UniProt Gene Name
PTN
UniProt Synonym Gene Names
HBNF1; NEGF1; PTN; HBBM; HBGF-8; HB-GAM; HBNF-1; OSF-1
UniProt Entry Name
PTN_HUMAN
Uniprot Description
PTN: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. Belongs to the pleiotrophin family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7q33
Cellular Component: extracellular space; endoplasmic reticulum
Molecular Function: heparin binding; growth factor activity; protein phosphatase inhibitor activity
Biological Process: nervous system development; positive regulation of cell division; positive regulation of cell proliferation; negative regulation of catalytic activity; learning; transmembrane receptor protein tyrosine phosphatase signaling pathway; bone mineralization
Research Articles on PTN
Similar Products
Product Notes
The PTN ptn (Catalog #AAA175297) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Pleiotrophin antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Pleiotrophin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the PTN ptn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Pleiotrophin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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