Western Blot (WB)
(Western Blot (WB) analysis of p-PLD2 (Y169) pAb at 1:500 dilutionLane1:HEK293T whole cell lysate (40ug) Lane2:C6 whole cell lysate (40ug) Lane3:The Embryo tissue lysate of Mouse (40ug) Lane4:A549 whole cell lysate (40ug) Lane5:Hela whole cell lysate (40ug))
Rabbit PLD2 Polyclonal Antibody | anti-PLD2 antibody
PLD2 (Phospho-Y169) Polyclonal Antibody
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot (WB) analysis of p-PLD2 (Y169) pAb at 1:500 dilutionLane1:HEK293T whole cell lysate (40ug) Lane2:C6 whole cell lysate (40ug) Lane3:The Embryo tissue lysate of Mouse (40ug) Lane4:A549 whole cell lysate (40ug) Lane5:Hela whole cell lysate (40ug))
Western Blot (WB)
(Western Blot (WB) analysis of p-PLD2 (Y169) pAb at 1:500 dilutionLane1:HEK293T whole cell lysate (40ug) Lane2:C6 whole cell lysate (40ug) Lane3:The Embryo tissue lysate of Mouse (40ug) Lane4:A549 whole cell lysate (40ug) Lane5:Hela whole cell lysate (40ug))
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Uniprot Description
PLD2: a phosphatidylcholine-specific phospholipase D. Catalyzes the hydrolysis of PC to produce phosphatidic acid and choline. Activated as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. May function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control. Enriched in caveolae; may be involved in MEK/ERK signaling cascades induced by the VEGF/VEGFR-2/PKC-delta pathway in endothelial cells. Three alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Phospholipase
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: endoplasmic reticulum membrane; brush border membrane; plasma membrane
Molecular Function: protein binding; phospholipase D activity; phosphoinositide binding
Biological Process: G-protein coupled receptor internalization; phosphatidylglycerol biosynthetic process; small GTPase mediated signal transduction; phospholipid metabolic process; glycerophospholipid biosynthetic process; innate immune response; phosphatidic acid biosynthetic process; cytoskeleton organization and biogenesis; lipid catabolic process
Research Articles on PLD2
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Product Notes
The PLD2 pld2 (Catalog #AAA3005408) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PLD2 (Phospho-Y169) Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PLD2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:1000. Researchers should empirically determine the suitability of the PLD2 pld2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLD2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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