Western Blot (WB)
(SH-SY5Y cells were subjected to SDS PAGE followed by western blot with MBS7602759 (PLCD3 Antibody) at dilution of 1:600)
Rabbit PLCD3 Polyclonal Antibody | anti-PLCD3 antibody
PLCD3 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(SH-SY5Y cells were subjected to SDS PAGE followed by western blot with MBS7602759 (PLCD3 Antibody) at dilution of 1:600)
Western Blot (WB)
(SH-SY5Y cells were subjected to SDS PAGE followed by western blot with MBS7602759 (PLCD3 Antibody) at dilution of 1:600)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]
Uniprot Description
PLCD3: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.
Protein type: EC 3.1.4.11; Phospholipase; Carbohydrate Metabolism - inositol phosphate
Chromosomal Location of Human Ortholog: 17q21.31
Cellular Component: cleavage furrow; cytosol; plasma membrane
Molecular Function: metal ion binding; phosphoinositide phospholipase C activity; signal transducer activity
Biological Process: angiogenesis; inositol phosphate metabolic process; lipid catabolic process; regulation of cell proliferation
Research Articles on PLCD3
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Product Notes
The PLCD3 plcd3 (Catalog #AAA7602759) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PLCD3 Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PLCD3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the PLCD3 plcd3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLCD3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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