Western Blot (WB)
(Western blot analysis of PLCB1 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). PLCB1 (arrow) was detected using the purified Pab.)
Rabbit PLCB1 Polyclonal Antibody | anti-PLCB1 antibody
PLCB1 Antibody (C-term)
Western Blot (WB)
(Western blot analysis of PLCB1 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). PLCB1 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of PLCB1 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). PLCB1 (arrow) was detected using the purified Pab.)
Flow Cytometry (FC/FACS)
(PLCB1 Antibody (C-term) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Flow Cytometry (FC/FACS)
(PLCB1 Antibody (C-term) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)
Woodcock, E.A., et al. J. Mol. Cell. Cardiol. 47(5):676-683(2009)
Zhang, Y., et al. J. Recept. Signal Transduct. Res. 29(1):52-62(2009)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PLCB1: an enzyme that catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. Binds to calmodulin. Uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. Activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variant isoforms have been described.
Protein type: Phospholipase; EC 3.1.4.11; Carbohydrate Metabolism - inositol phosphate
Chromosomal Location of Human Ortholog: 20p12
Cellular Component: nuclear membrane; cytoplasm; nuclear chromatin; nuclear speck; cytosol; nucleus
Molecular Function: calmodulin binding; signal transducer activity; phosphatidylinositol-4,5-bisphosphate binding; protein homodimerization activity; enzyme binding; calcium ion binding; phosphoinositide phospholipase C activity; GTPase activator activity; lamin binding
Biological Process: fat cell differentiation; positive regulation of developmental growth; acetylcholine receptor signaling, muscarinic pathway; inositol phosphate metabolic process; glutamate signaling pathway; positive regulation of interleukin-12 production; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of JNK cascade; signal transduction; memory; positive regulation of myoblast differentiation; synaptic transmission; positive regulation of embryonic development; insulin-like growth factor receptor signaling pathway; phosphatidylinositol metabolic process; cerebral cortex development; negative regulation of transcription, DNA-dependent; G2/M transition of mitotic cell cycle; regulation of G-protein coupled receptor protein signaling pathway; lipid catabolic process; positive regulation of GTPase activity
Disease: Epileptic Encephalopathy, Early Infantile, 12
Research Articles on PLCB1
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Product Notes
The PLCB1 plcb1 (Catalog #AAA9211298) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1148-1176. The PLCB1 Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine, Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's PLCB1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS). WB~~1:1000. Researchers should empirically determine the suitability of the PLCB1 plcb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLCB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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