Western Blot (WB)
(Western blot analysis of extracts from COS-7 cells, treated with PMA (125ng/ml, 30mins), using PKA-R2beta (Phospho-Ser113) antibody.)
Rabbit anti-Human, mouse PKA-R2beta (Phospho-Ser113) Polyclonal Antibody | anti-PRKAR2B antibody
PKA-R2beta (Phospho-Ser113) Antibody
Western Blot (WB)
(Western blot analysis of extracts from COS-7 cells, treated with PMA (125ng/ml, 30mins), using PKA-R2beta (Phospho-Ser113) antibody.)
Western Blot (WB)
(Western blot analysis of extracts from COS-7 cells, treated with PMA (125ng/ml, 30mins), using PKA-R2beta (Phospho-Ser113) antibody.)
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.W.,et al.Science 300:767-772(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Han G.,et al.Proteomics 8:1346-1361(2008).
NCBI and Uniprot Product Information
NCBI Description
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
Uniprot Description
PKAR2B: a regulatory subunit of cAMP-regulated protein kinase. The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
Protein type: Mitochondrial; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 7q22
Cellular Component: centrosome; cytoplasm; plasma membrane; dendritic spine; dendritic shaft; cytosol; cAMP-dependent protein kinase complex
Molecular Function: cAMP-dependent protein kinase inhibitor activity; ubiquitin protein ligase binding; cAMP-dependent protein kinase regulator activity; cAMP binding
Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; organelle organization and biogenesis; activation of protein kinase A; learning; fatty acid metabolic process; signal transduction; phospholipase C activation; energy reserve metabolic process; innate immune response; renal water homeostasis; mitotic cell cycle; blood coagulation; G2/M transition of mitotic cell cycle; transmembrane transport; regulation of insulin secretion
Research Articles on PRKAR2B
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Product Notes
The PRKAR2B prkar2b (Catalog #AAA9210997) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PKA-R2beta (Phospho-Ser113) Antibody reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PKA-R2beta (Phospho-Ser113) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PRKAR2B prkar2b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PKA-R2beta (Phospho-Ser113), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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