Rabbit anti-Human PJVK Polyclonal Antibody | anti-DFNB59 antibody

PJVK, ID (PJVK, DFNB59, Pejvakin, Autosomal recessive deafness type 59 protein)

Cat. Num. AAA6010960

• Gene Names: DFNB59; PJVK
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PJVK; Polyclonal Antibody; ID (PJVK; DFNB59; Pejvakin; Autosomal recessive deafness type 59 protein); Anti -PJVK; anti-DFNB59 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-DFNB59 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: PJVK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-197 amino acids from the Central region of human PJVK.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(PJVK Antibody (Center) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the PJVK antibody detected the PJVK protein (arrow).)

Related Product Information for anti-DFNB59 antibody

The protein encoded by this gene is a member of the gasdermin family, a family which is found only in vertebrates. The encoded protein is required for the proper function of auditory pathway neurons. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal recessive type 59 (DFNB59).

Product Categories/Family for anti-DFNB59 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 111607457
• NCBI GeneID: 494513
• NCBI Accession #: NP_001036167.1
• NCBI GenBank Nucleotide #: NM_001042702.3
• UniProt Accession #: Q0ZLH3; A0PK14; B9EJE2
• Molecular Weight: 39,913 Da
• NCBI Official Full Name: pejvakin
• NCBI Official Synonym Full Names: deafness, autosomal recessive 59
• NCBI Official Symbol: DFNB59
• NCBI Official Synonym Symbols: PJVK
• NCBI Protein Information: pejvakin; autosomal recessive deafness type 59 protein
• UniProt Protein Name: Pejvakin
• UniProt Gene Name: DFNB59
• UniProt Synonym Gene Names: PJVK
• UniProt Entry Name: PJVK_HUMAN

NCBI Description

The protein encoded by this gene is a member of the gasdermin family, a family which is found only in vertebrates. The encoded protein is required for the proper function of auditory pathway neurons. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal recessive type 59 (DFNB59). [provided by RefSeq, Dec 2008]

Uniprot Description

DFNB59: Essential in the activity of auditory pathway neurons. Defects in PJVK are the cause of deafness autosomal recessive type 59 (DFNB59). DFNB59 is a form of sensorineural hearing impairment with absent or severely abnormal auditory brainstem response but normal otoacoustic emissions (auditory neuropathy or auditory dys-synchrony). Auditory neuropathies result from a lesion in the area including the inner hair cells, connections between the inner hair cells and the cochlear branch of the auditory nerve, the auditory nerve itself and auditory pathways of the brainstem. Belongs to the gasdermin family.

Chromosomal Location of Human Ortholog: 2q31.2

Cellular Component: cell soma

Biological Process: sensory perception of sound

Disease: Deafness, Autosomal Recessive 59