Rabbit PIP Polyclonal Antibody | anti-PIP antibody

PIP Polyclonal Antibody

Cat. Num. AAA3011543

• Gene Names: PIP; GPIP4; GCDFP15; GCDFP-15
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: PIP; Polyclonal Antibody; PIP Polyclonal Antibody; Prolactin-inducible protein; Gross cystic disease fluid protein 15; GCDFP-15; Prolactin-induced protein; Secretory actin-binding protein; SA BP; gp17; GCDFP15; GPIP4; anti-PIP antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: PIP polyclonal antibody detects endogenous levels of PIP protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 146

• Applicable Applications for anti-PIP antibody: Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: IHC: 1:50-1:100; IF: 1:50-1:100
• Immunogen: Recombinant full length Human PIP.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded rat lung using PIP antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate using PIP antibody at dilution of 1:100 (40x lens).)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse lung using PIP antibody at dilution of 1:100 (40x lens).)

Related Product Information for anti-PIP antibody

Gross cystic disease fluid protein 15 (GCDFP-15) is a major protein component of benign breast gross cysts. It is a known marker of breast cancer, as it is found in approximately 50% of all breast cancer specimens. GCDFP-15, also known as PIP, for prolactin inducible protein, is a prolactin and androgen controlled protein. It is detectable in saliva, tears, sweat, seminal plasma, submucosal glands of the lung and amniotic fluid. PIP, the gene encoding GCDFP-15 is expressed in exocrine glands and, in pathologic conditions, in breast cysts and breast cancers exhibiting apocrine features. The PIP gene maps to the long arm of chromosome 7, a region frequently altered in mammary tumors.

NCBI and Uniprot Product Information

• NCBI GI #: 4505821
• NCBI GeneID: 5304
• NCBI Accession #: NP_002643.1
• NCBI GenBank Nucleotide #: NP_002643.1
• UniProt Accession #: P12273
• Molecular Weight: ~ 17kDa
• NCBI Official Full Name: prolactin-inducible protein
• NCBI Official Synonym Full Names: prolactin induced protein
• NCBI Official Symbol: PIP
• NCBI Official Synonym Symbols: GPIP4; GCDFP15; GCDFP-15
• NCBI Protein Information: prolactin-inducible protein
• UniProt Protein Name: Prolactin-inducible protein
• Protein Family: Proline iminopeptidase
• UniProt Gene Name: PIP
• UniProt Synonym Gene Names: GCDFP15; GPIP4; GCDFP-15; SABP
• UniProt Entry Name: PIP_HUMAN

Uniprot Description

PIP: Belongs to the PIP family.

Protein type: Secreted; Cytoskeletal; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: extracellular space; apical plasma membrane; nucleus

Molecular Function: protein dimerization activity; protein binding; IgG binding; actin binding; glycoprotein binding; aspartic-type endopeptidase activity

Biological Process: retinal homeostasis; regulation of immune system process; detection of chemical stimulus involved in sensory perception of bitter taste; proteolysis