Western Blot (WB)
(PIGV Antibody (C-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the PIGV antibody detected the PIGV protein (arrow).)
Rabbit anti-Human PIGV Polyclonal Antibody | anti-PIGV antibody
PIGV Antibody (C-term)
Western Blot (WB)
(PIGV Antibody (C-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the PIGV antibody detected the PIGV protein (arrow).)
Western Blot (WB)
(PIGV Antibody (C-term) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the PIGV antibody detected the PIGV protein (arrow).)
that anchors many proteins to the cell surface. The biosynthetic
pathway of GPI is mediated by sequential addition of sugars and
other components to phosphatidylinositol. PIGV adds the second
mannose to the GPI core (Kang et al., 2005 [PubMed
15623507]).
Kang, J.Y., et al. J. Biol. Chem. 280(10):9489-9497(2005)
Fabre, A.L., et al. FEBS J. 272(5):1160-1168(2005)
Kinoshita, T., et al. Curr Opin Chem Biol 4(6):632-638(2000)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a mannosyltransferase enzyme involved in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a complex glycolipid that functions as a membrane anchor for many proteins and plays a role in multiple cellular processes including protein sorting and signal transduction. The encoded protein is localized to the endoplasmic reticulum and transfers the second mannose to the GPI backbone. Mutations in this gene are associated with hyperphosphatasia mental retardation syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Uniprot Description
PIGV: Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly. Defects in PIGV are the cause of hyperphosphatasia with mental retardation type 1 (HPMRS1). It is a syndrome characterized by elevated serum alkaline phosphatase, severe mental retardation, seizures, hypotonia, facial dysmorphism, and hypoplastic terminal phalanges. Belongs to the PIGV family.
Protein type: Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; EC 2.4.1.-; Membrane protein, multi-pass; Transferase; Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: mannosyltransferase activity
Biological Process: cellular protein metabolic process; preassembly of GPI anchor in ER membrane; GPI anchor biosynthetic process; C-terminal protein lipidation; post-translational protein modification
Disease: Hyperphosphatasia With Mental Retardation Syndrome 1
Research Articles on PIGV
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Product Notes
The PIGV pigv (Catalog #AAA9209053) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 343-371. The PIGV Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PIGV can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PIGV pigv for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PIGV, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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