Rabbit anti-Mouse PIGU Polyclonal Antibody | anti-PIGU antibody

PIGU (Phosphatidylinositol Glycan Anchor Biosynthesis Class U Protein, Cell Division Cycle Protein 91-like 1, Protein CDC91-like 1, GPI Transamidase Component PIG-U, PIGU, CDC91L1) (MaxLight 650)

Cat. Num. AAA6458150

• Gene Names: PIGU; GAB1; CDC91L1
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PIGU; Polyclonal Antibody; PIGU (Phosphatidylinositol Glycan Anchor Biosynthesis Class U Protein; Cell Division Cycle Protein 91-like 1; Protein CDC91-like 1; GPI Transamidase Component PIG-U; CDC91L1) (MaxLight 650); anti-PIGU antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse PIGU. Species Crossreactivity: mouse
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-PIGU antibody: Western Blot (WB)
• Application Notes: WB: 1:2000; Applications are based on unconjugated antibody.
• Immunogen: KLH conjugated synthetic peptide corresponding to aa102-134 from human PIGU.
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-PIGU antibody

Antibodies; Enzymes; Phosphatase

References

Hong Y., et al. Mol. Biol. Cell 14:1780-1789(2003). Guo Z., et al. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases. Lin L., et al. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. Clark H.F., et al. Genome Res. 13:2265-2270(2003). Otsuki T., et al. DNA Res. 12:117-126(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 17998700
• NCBI GeneID: 128869
• NCBI Accession #: NP_536724.1
• NCBI GenBank Nucleotide #: NM_080476.4
• UniProt Accession #: Q9H490; Q7Z489; Q8N2F2
• Molecular Weight: 47,611 Da
• NCBI Official Full Name: phosphatidylinositol glycan anchor biosynthesis class U protein
• NCBI Official Synonym Full Names: phosphatidylinositol glycan anchor biosynthesis, class U
• NCBI Official Symbol: PIGU
• NCBI Official Synonym Symbols: GAB1; CDC91L1
• NCBI Protein Information: phosphatidylinositol glycan anchor biosynthesis class U protein
• UniProt Protein Name: Phosphatidylinositol glycan anchor biosynthesis class U protein
• Protein Family: Piguamerin
• UniProt Gene Name: PIGU
• UniProt Synonym Gene Names: CDC91L1; Protein CDC91-like 1
• UniProt Entry Name: PIGU_HUMAN

NCBI Description

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]

Uniprot Description

PIGU: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI. Belongs to the PIGU family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane; integral to endoplasmic reticulum membrane; GPI-anchor transamidase complex

Molecular Function: GPI-anchor transamidase activity

Biological Process: regulation of JAK-STAT cascade; cellular protein metabolic process; attachment of GPI anchor to protein; GPI anchor biosynthetic process; C-terminal protein lipidation; post-translational protein modification