Rabbit anti-Mouse PIGU Polyclonal Antibody | anti-PIGU antibody

PIGU (Phosphatidylinositol Glycan Anchor Biosynthesis Class U Protein, Cell Division Cycle Protein 91-like 1, Protein CDC91-like 1, GPI Transamidase Component PIG-U, PIGU, CDC91L1) (AP)

Cat. Num. AAA6458142

• Gene Names: PIGU; GAB1; CDC91L1
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PIGU; Polyclonal Antibody; PIGU (Phosphatidylinositol Glycan Anchor Biosynthesis Class U Protein; Cell Division Cycle Protein 91-like 1; Protein CDC91-like 1; GPI Transamidase Component PIG-U; CDC91L1) (AP); anti-PIGU antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse PIGU. Species Crossreactivity: mouse
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.

• Applicable Applications for anti-PIGU antibody: Western Blot (WB)
• Application Notes: WB: 1:2000; Applications are based on unconjugated antibody.
• Immunogen: KLH conjugated synthetic peptide corresponding to aa102-134 from human PIGU.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-PIGU antibody

Antibodies; Enzymes; Phosphatase

References

Hong Y., et al. Mol. Biol. Cell 14:1780-1789(2003). Guo Z., et al. Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases. Lin L., et al. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. Clark H.F., et al. Genome Res. 13:2265-2270(2003). Otsuki T., et al. DNA Res. 12:117-126(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 17998700
• NCBI GeneID: 128869
• NCBI Accession #: NP_536724.1
• NCBI GenBank Nucleotide #: NM_080476.4
• UniProt Accession #: Q9H490; Q7Z489; Q8N2F2
• Molecular Weight: 47,611 Da
• NCBI Official Full Name: phosphatidylinositol glycan anchor biosynthesis class U protein
• NCBI Official Synonym Full Names: phosphatidylinositol glycan anchor biosynthesis, class U
• NCBI Official Symbol: PIGU
• NCBI Official Synonym Symbols: GAB1; CDC91L1
• NCBI Protein Information: phosphatidylinositol glycan anchor biosynthesis class U protein
• UniProt Protein Name: Phosphatidylinositol glycan anchor biosynthesis class U protein
• Protein Family: Piguamerin
• UniProt Gene Name: PIGU
• UniProt Synonym Gene Names: CDC91L1; Protein CDC91-like 1
• UniProt Entry Name: PIGU_HUMAN

NCBI Description

The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]

Uniprot Description

PIGU: Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI. Belongs to the PIGU family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane; integral to endoplasmic reticulum membrane; GPI-anchor transamidase complex

Molecular Function: GPI-anchor transamidase activity

Biological Process: regulation of JAK-STAT cascade; cellular protein metabolic process; attachment of GPI anchor to protein; GPI anchor biosynthetic process; C-terminal protein lipidation; post-translational protein modification