Western Blot (WB)
(PIGO Antibody (C-term) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the PIGO antibody detected the PIGO protein (arrow).)
Rabbit anti-Human PIGO Polyclonal Antibody | anti-PIGO antibody
PIGO Antibody (C-term)
Western Blot (WB)
(PIGO Antibody (C-term) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the PIGO antibody detected the PIGO protein (arrow).)
Western Blot (WB)
(PIGO Antibody (C-term) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the PIGO antibody detected the PIGO protein (arrow).)
glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The
GPI-anchor is a glycolipid which contains three mannose molecules
in its core backbone. The GPI-anchor is found on many blood cells
and serves to anchor proteins to the cell surface. This protein is
involved in the transfer of ethanolaminephosphate (EtNP) to the
third mannose in GPI. At least two alternatively spliced
transcripts encoding distinct isoforms have been found for this
gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Uniprot Description
PIGO: Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, multi-pass; Membrane protein, integral; EC 2.-.-.-; Transferase; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane
Molecular Function: transferase activity
Biological Process: cellular protein metabolic process; preassembly of GPI anchor in ER membrane; GPI anchor biosynthetic process; C-terminal protein lipidation; post-translational protein modification
Disease: Hyperphosphatasia With Mental Retardation Syndrome 2
Research Articles on PIGO
Similar Products
Product Notes
The PIGO pigo (Catalog #AAA9203330) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 955-983. The PIGO Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PIGO can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PIGO pigo for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PIGO, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
