Rabbit anti-Human PHOX2A Polyclonal Antibody | anti-PHOX2A antibody

PHOX2A Rabbit Polyclonal

Cat. Num. AAA7602640

• Gene Names: PHOX2A; ARIX; FEOM2; NCAM2; PMX2A; CFEOM2
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PHOX2A; Polyclonal Antibody; PHOX2A Rabbit Polyclonal; anti-PHOX2A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 284

• Applicable Applications for anti-PHOX2A antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Paired-like homeobox 2a
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(SH-SY5Y cells were subjected to SDS PAGE followed by western blot with MBS7602640 (PHOX2A Antibody) at dilution of 1:600)

NCBI and Uniprot Product Information

• NCBI GI #: 46249382
• NCBI GeneID: 401
• NCBI Accession #: NP_005160.2
• NCBI GenBank Nucleotide #: NM_005169.3
• Molecular Weight: 29,653 Da
• NCBI Official Full Name: paired mesoderm homeobox protein 2A
• NCBI Official Synonym Full Names: paired like homeobox 2a
• NCBI Official Symbol: PHOX2A
• NCBI Official Synonym Symbols: ARIX; FEOM2; NCAM2; PMX2A; CFEOM2
• NCBI Protein Information: paired mesoderm homeobox protein 2A
• UniProt Protein Name: Paired mesoderm homeobox protein 2A
• Protein Family: Paired mesoderm homeobox protein
• UniProt Gene Name: PHOX2A
• UniProt Synonym Gene Names: ARIX; PMX2A
• UniProt Entry Name: PHX2A_HUMAN

NCBI Description

The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008]

Uniprot Description

PHOX2A: May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype. Defects in PHOX2A are the cause of congenital fibrosis of extraocular muscles type 2 (CFEOM2). CFEOM encompasses several different inherited strabismus syndromes characterized by congenital restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. CFEOM is characterized clinically by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. CFEOM2 may result from the aberrant development of the oculomotor (nIII), trochlear (nIV) and abducens (nVI) cranial nerve nuclei. Belongs to the paired homeobox family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 11q13.2

Cellular Component: nuclear chromatin

Molecular Function: transcription factor activity

Biological Process: locus ceruleus development; midbrain development; oculomotor nerve formation; positive regulation of transcription from RNA polymerase II promoter; regulation of respiratory gaseous exchange; somatic motor neuron differentiation; sympathetic nervous system development; transcription, DNA-dependent; trochlear nerve formation

Disease: Fibrosis Of Extraocular Muscles, Congenital, 2