Immunohistochemistry (IHC)
(Immunostaining of human larynx taste bud showing specific labeling of PLC beta2 (red) and GNAT3 (green). Photo courtesy of Mei Li, University of Colorado-Anschutz MC.)
Rabbit Phospholipase C B2 (PLCB2) Polyclonal Antibody | anti-PLCB2 antibody
Phospholipase C B2 (PLCB2)
Applications
Immunohistochemistry, Immunofluorescence
Purity
Antigen Affinity Purified from Pooled Serum
Synonyms
Phospholipase C B2 (PLCB2); Polyclonal Antibody; 1-phosphatidylinositol-4 antibody; 1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase beta-2 antibody; FLJ38135 antibody; Phosphoinositide phospholipase C-beta-2 antibody; Phospholipase C-beta-2 antibody; PLC-beta-2 antibody; Plcb2 antibody; PLCB2_HUMAN antibody; anti-PLCB2 antibody
Host
Rabbit
Clonality
Polyclonal
Purity/Purification
Antigen Affinity Purified from Pooled Serum
Form/Format
100ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100ug BSA per ml and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
Applicable Applications for anti-PLCB2 antibody
Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
IF: 1:1000
IHC: 1:1000
IHC: 1:1000
Species Positively Tested
Human, non-Human primate
Immunogen Species
Human
Immunogen Information
Peptide corresponding to amino acid residues from the C-terminal region of human PLC beta2
Antigen
The antigen is a peptide corresponding to amino acid residues from the C-terminal region of human PLC beta2. Prepared from pooled rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.
Preparation and Storage
Storage at -20 degree C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at-20 degree C.
Shipping: Blue Ice
Country of Origin: USA
Shipping: Blue Ice
Country of Origin: USA
Immunohistochemistry (IHC)
(Immunostaining of human larynx taste bud showing specific labeling of PLC beta2 (red) and GNAT3 (green). Photo courtesy of Mei Li, University of Colorado-Anschutz MC.)
Immunohistochemistry (IHC)
(Immunostaining of human larynx taste bud showing specific labeling of PLC beta2 (red) and GNAT3 (green). Photo courtesy of Mei Li, University of Colorado-Anschutz MC.)
Related Product Information for anti-PLCB2 antibody
Phospholipases are quite common enzymes that are present in a broad range of organisms, including bacteria, yeast, plants, animals, and viruses. Phospholipase C (PLC) constitutes a class of enzymes that cleave phospholipids on the diacylglycerol (DAG) side of the phosphodiester bond (Cocco et al., 2015). A growing body of evidence supports the role of phospholipase C (PLC) in the invasion and metastasis of different tumors, including breast cancer (Bertagnolo et al., 2006). PLC-beta2 has been shown to be required for sweet, umami and bitter taste perception in mammals (Zhang et al., 2003). Data also suggests that PLC-beta2 serves an unappreciated role assembling components of the p38MAPK signaling module (Barr et al., 2002).
Product Categories/Family for anti-PLCB2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
134,024 Da
NCBI Official Full Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
NCBI Official Synonym Full Names
phospholipase C, beta 2
NCBI Official Symbol
PLCB2
NCBI Protein Information
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; PLC-beta-2; phospholipase C-beta-2; phosphoinositide phospholipase C-beta-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2
UniProt Protein Name
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Protein Family
UniProt Gene Name
PLCB2
UniProt Synonym Gene Names
PLC-beta-2
UniProt Entry Name
PLCB2_HUMAN
Uniprot Description
PLCB2: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Phospholipase; Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11
Chromosomal Location of Human Ortholog: 15q15
Cellular Component: cytosol
Molecular Function: signal transducer activity; calcium ion binding; phosphoinositide phospholipase C activity; phospholipase C activity
Biological Process: synaptic transmission; inositol phosphate metabolic process; metabolic process; phospholipase C activation; phospholipid metabolic process; sensory perception of bitter taste; lipid catabolic process
Research Articles on PLCB2
Similar Products
Product Notes
The PLCB2 plcb2 (Catalog #AAA502235) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Phospholipase C B2 (PLCB2) can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunofluorescence (IF). IF: 1:1000 IHC: 1:1000. Researchers should empirically determine the suitability of the PLCB2 plcb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phospholipase C B2 (PLCB2), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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