Western Blot (WB)
(The anti-Phospho-CDC6-S54 Pab is used in Western blot to detect Phospho-CDC6-S54 in Ramos tissue lysate)
Rabbit anti-Human Phospho-CDC6 (S54) Polyclonal Antibody | anti-CDC6 antibody
Phospho-CDC6 (S54) Antibody
Western Blot (WB)
(The anti-Phospho-CDC6-S54 Pab is used in Western blot to detect Phospho-CDC6-S54 in Ramos tissue lysate)
Western Blot (WB)
(The anti-Phospho-CDC6-S54 Pab is used in Western blot to detect Phospho-CDC6-S54 in Ramos tissue lysate)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Yim, H., et al., Mol. Biol. Cell 14(10):4250-4259 (2003).
Clay-Farrace, L., et al., EMBO J. 22(3):704-712 (2003).
Pelizon, C., et al., EMBO Rep. 3(8):780-784 (2002).
Bermejo, R., et al., Mol. Biol. Cell 13(11):3989-4000 (2002).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Uniprot Description
CDC6: Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1. Belongs to the CDC6/cdc18 family.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 17q21.3
Cellular Component: nucleoplasm; Golgi apparatus; spindle pole; cytoplasm; spindle midzone; nucleus; cytosol
Molecular Function: protein binding; nucleotide binding; chromatin binding; kinase binding; ATP binding
Biological Process: positive regulation of cytokinesis; mitosis; traversing start control point of mitotic cell cycle; regulation of mitotic metaphase/anaphase transition; positive regulation of chromosome segregation; G1/S-specific transcription in mitotic cell cycle; negative regulation of cell proliferation; negative regulation of DNA replication; cell division; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; DNA replication; DNA replication checkpoint; G1/S transition of mitotic cell cycle
Disease: Meier-gorlin Syndrome 5
Research Articles on CDC6
Similar Products
Product Notes
The CDC6 cdc6 (Catalog #AAA9209507) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-CDC6 (S54) Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Phospho-CDC6 (S54) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the CDC6 cdc6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phospho-CDC6 (S54), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
