Rabbit PHAP III Polyclonal Antibody | anti-PHAP III antibody

PHAP III Antibody

Cat. Num. AAA9414557

• Gene Names: ANP32E; LANPL; LANP-L
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: PHAP III; Polyclonal Antibody; PHAP III Antibody; anti-PHAP III antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: PHAP III has no cross-reaction to PHAP I and PHAP I2a.
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 268

• Applicable Applications for anti-PHAP III antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: PHAP III antibody was raised with a synthetic peptide corresponding to amino acids close to carboxy terminus of human PHAP III.
• Target Name: PHAP III
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of PHAP III expression in human A549 (A) and HepG2 (B) cells, and rat testis (C) with PHAP antibody III at 1 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of PHAP III in human small intestine tissue with PHAP III antibody at 2 ug/mL.)

Related Product Information for anti-PHAP III antibody

Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.

Product Categories/Family for anti-PHAP III antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 13569879
• NCBI GeneID: 81611
• NCBI Accession #: NP_112182
• NCBI GenBank Nucleotide #: NM_030920.4
• Molecular Weight: 25,125 Da
• NCBI Official Full Name: acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1
• NCBI Official Synonym Full Names: acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
• NCBI Official Symbol: ANP32E
• NCBI Official Synonym Symbols: LANPL; LANP-L
• NCBI Protein Information: acidic leucine-rich nuclear phosphoprotein 32 family member E
• UniProt Protein Name: Acidic leucine-rich nuclear phosphoprotein 32 family member E
• UniProt Gene Name: ANP32E
• UniProt Synonym Gene Names: LANP-L
• UniProt Entry Name: AN32E_HUMAN

Uniprot Description

LANP-L: Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis process by modulating PP2A activity. Belongs to the ANP32 family.

Protein type: Motility/polarity/chemotaxis; Inhibitor; Protein phosphatase, regulatory subunit; Vesicle

Chromosomal Location of Human Ortholog: 1q21.2

Cellular Component: cytoplasmic membrane-bound vesicle; nucleus

Molecular Function: phosphatase inhibitor activity; histone binding

Biological Process: negative regulation of catalytic activity; histone exchange