Western Blot (WB)
(PEX1 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the PEX1 antibody detected the PEX1 protein (arrow).)
Rabbit anti-Human PEX1 Polyclonal Antibody | anti-PEX1 antibody
PEX1 Antibody (Center)
Western Blot (WB)
(PEX1 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the PEX1 antibody detected the PEX1 protein (arrow).)
Western Blot (WB)
(PEX1 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the PEX1 antibody detected the PEX1 protein (arrow).)
large group of ATPases associated with diverse cellular activities.
This protein is cytoplasmic but is often anchored to a peroxisomal
membrane where it forms a heteromeric complex and plays a role in
the import of proteins into peroxisomes and peroxisome biogenesis.
Mutations in this gene have been associated with complementation
group 1 peroxisomal disorders such as neonatal
adrenoleukodystrophy, infantile Refsum disease, and Zellweger
syndrome.
Yik, W.Y., et al. Hum. Mutat. 30 (3), E467-E480 (2009) :
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Tamura, S., et al. J. Biol. Chem. 281(38):27693-27704(2006)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Description
PEX1: Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Belongs to the AAA ATPase family. Interacts directly with PEX6. Interacts indirectly with PEX26, via its interaction with PEX6.
Protein type: Hydrolase
Chromosomal Location of Human Ortholog: 7q21.2
Cellular Component: peroxisomal membrane; intracellular membrane-bound organelle; cytoplasm; peroxisome; cytosol
Molecular Function: protein C-terminus binding; protein binding; protein complex binding; ATPase activity, coupled; ATP binding
Biological Process: peroxisome organization and biogenesis; protein targeting to peroxisome; metabolic process; microtubule-based peroxisome localization; protein import into peroxisome matrix
Disease: Peroxisome Biogenesis Disorder 1a (zellweger); Peroxisome Biogenesis Disorder 1b
Research Articles on PEX1
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Product Notes
The PEX1 pex1 (Catalog #AAA9213942) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 599-628. The PEX1 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PEX1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PEX1 pex1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PEX1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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