Rabbit anti-Mouse Per2 Polyclonal Antibody | anti-Per2 antibody

Per2 Antibody

Cat. Num. AAA9458550

• Gene Names: Per2; mPer2; mKIAA0347
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
• Synonyms: Per2; Polyclonal Antibody; Per2 Antibody; Period circadian protein homolog 2; anti-Per2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Purity/Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
• Form/Format: Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH7.4, 150mM NaCl, 0.02% sodium azide and 85% glycerol
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-Per2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: Peptide-KLH
• Preparation and Storage: Store at -20 degree C for long term preservation (recommended). Store at 39 degree C for short term use.

Related Product Information for anti-Per2 antibody

Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndrome and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. PER1 and PER2 proteins transport CRY1 and CRY2 into the nucleus with appropriate circadian timing, but also contribute directly to repression of clock-controlled target genes through interaction with several classes of RNA-binding proteins, helicases and others transcriptional repressors. PER appears to regulate circadian control of transcription by at least three different modes.

Product Categories/Family for anti-Per2 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 153792236
• NCBI GeneID: 18627
• NCBI Accession #: NP_035196.2
• NCBI GenBank Nucleotide #: NM_011066.3
• UniProt Accession #: O54943; O54954
• Molecular Weight: 135,881 Da
• NCBI Official Full Name: period circadian protein homolog 2
• NCBI Official Synonym Full Names: period circadian clock 2
• NCBI Official Symbol: Per2
• NCBI Official Synonym Symbols: mPer2; mKIAA0347
• NCBI Protein Information: period circadian protein homolog 2; period 2; period homolog 2; circadian clock protein PERIOD 2
• UniProt Protein Name: Period circadian protein homolog 2
• Protein Family: Period circadian protein
• UniProt Gene Name: Per2
• UniProt Synonym Gene Names: mPER2
• UniProt Entry Name: PER2_MOUSE