Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Mouse Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) Polyclonal Antibody | anti-PIN1 antibody
Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1)
MGHHHHHHSGSEF-ADEEKLPPG WEKRMSRSSG RVYYFNHITN ASQWERPSGG STVGGSSKNG QGEPAKVRCS HLLVKHSQSR RPSSWRQEKI TRSKEEALEL INGYIQKIKS GEEDFESLAS QFSDCSSAKA RGDLGPFSRG QMQKPFEDAS FALRTGEMSG PVFTDSGIHI ILRTE
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded kidney tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded kidney tissue))
NCBI and Uniprot Product Information
Uniprot Description
PIN1: a member of the parvulin family of peptidyl-prolyl isomerases (PPIase), has been implicated in the G2-M transition of the cell cycle. Has two distinct functional domains: an N-terminal WW domain and a C-terminal PPlase domain. Pin1 interacts with a series of mitotic phosphoproteins, including Plk1, cdc25C and cdc27, catalyzing pSer-Pro or pThr/Pro cis/trans isomerizations. Displays a preference for an acidic residue n-terminal to the isomerized proline bond.
Protein type: EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 9 A3|9 7.6 cM
Cellular Component: cytoplasm; cytosol; midbody; mitochondrion; neuron projection; nucleoplasm; nucleus
Molecular Function: beta-catenin binding; GTPase activating protein binding; isomerase activity; mitogen-activated protein kinase kinase binding; motor activity; peptidyl-prolyl cis-trans isomerase activity; phosphoserine binding; phosphothreonine residue binding; protein binding
Biological Process: cell cycle; negative regulation of cell motility; negative regulation of ERK1 and ERK2 cascade; negative regulation of neuron apoptosis; negative regulation of protein binding; negative regulation of protein catabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; neuron differentiation; positive regulation of canonical Wnt signaling pathway; positive regulation of GTPase activity; positive regulation of neuron apoptotic process; positive regulation of protein dephosphorylation; positive regulation of protein phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of ubiquitin-protein transferase activity; protein stabilization; regulation of cell proliferation; regulation of cytokinesis; regulation of protein localization to nucleus; synapse organization
Research Articles on PIN1
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Product Notes
The PIN1 pin1 (Catalog #AAA2003297) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the PIN1 pin1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with a His-tag and its sequence is listed below. MGHHHHHHSG SEF-ADEEKL PPG WEKRMSRSSG RVYYFNHITN ASQWERPSGG STVGGSSKNG QGEPAKVRCS HLLVKHSQSR RPSSWRQEKI TRSKEEALEL INGYIQKIKS GEEDFESLAS QFSDCSSAKA RGDLGPFSRG QMQKPFEDAS FALRTGEMSG PVFTDSGIHI ILRTE. It is sometimes possible for the material contained within the vial of "Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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