Rabbit anti-Human peptide YY Polyclonal Antibody | anti-PYY antibody

peptide YY Rabbit Polyclonal

Cat. Num. AAA7602543

• Gene Names: PYY; PYY1; PYY-I
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: peptide YY; Polyclonal Antibody; peptide YY Rabbit Polyclonal; anti-PYY antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 97

• Applicable Applications for anti-PYY antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Immunogen: Peptide YY
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human pancreas slide using MBS7602543 (peptide YY antibody) at dilution of 1:50)

NCBI and Uniprot Product Information

• NCBI GI #: 300068956
• NCBI GeneID: 5697
• NCBI Accession #: NP_004151.3
• NCBI GenBank Nucleotide #: NM_004160.5
• Molecular Weight: 10,360 Da
• NCBI Official Full Name: peptide YY preproprotein
• NCBI Official Synonym Full Names: peptide YY
• NCBI Official Symbol: PYY
• NCBI Official Synonym Symbols: PYY1; PYY-I
• NCBI Protein Information: peptide YY
• UniProt Protein Name: Peptide YY
• Protein Family: Peptide
• UniProt Gene Name: PYY
• UniProt Synonym Gene Names: PYY
• UniProt Entry Name: PYY_HUMAN

NCBI Description

This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]

Uniprot Description

PYY: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. Belongs to the NPY family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: extracellular region; extracellular space

Molecular Function: G-protein-coupled receptor binding; hormone activity; neuropeptide hormone activity; protein binding

Biological Process: cell motility; cell proliferation; cell-cell signaling; cytoskeleton organization and biogenesis; digestion; eating behavior; feeding behavior; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; regulation of appetite

Disease: Obesity