Rabbit anti-Human PEG3 Polyclonal Antibody | anti-PEG3 antibody

PEG3 Rabbit pAb

Cat. Num. AAA4758613

• Gene Names: PEG3; PW1; ZNF904; ZSCAN24; ZKSCAN22
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: PEG3; Polyclonal Antibody; PEG3 Rabbit pAb; paternally expressed 3; PW1; ZNF904; ZSCAN24; ZKSCAN22; anti-PEG3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the follicles. Expression is highly repressed in glioma cell lines.
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-PEG3 antibody: ELISA (EIA), Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: ELISA: 1:5000-1:10,000; IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human PEG3
• Conjugation: Unconjugated
• Molecular Function: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells.
• Modification: Unmodified
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using 862819(PEG3 Antibody) at dilution 1/20.(Original magnification: ×200))

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using 862819(PEG3 Antibody) at dilution 1/20. (Original magnification: ×200))

Related Product Information for anti-PEG3 antibody

In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.

Product Categories/Family for anti-PEG3 antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 226053126
• NCBI GeneID: 5178
• NCBI Accession #: NP_001139656.1
• NCBI GenBank Nucleotide #: NM_001146184.1
• UniProt Accession #: Q9GZU2; P78418; Q5H9P9; Q7Z7H7; Q8TF75; Q9GZY2; A7E2B8; B4DIM4; C9JP50
• Molecular Weight: 180,827 Da
• NCBI Official Full Name: paternally-expressed gene 3 protein isoform 1
• NCBI Official Synonym Full Names: paternally expressed 3
• NCBI Official Symbol: PEG3
• NCBI Official Synonym Symbols: PW1; ZNF904; ZSCAN24; ZKSCAN22
• NCBI Protein Information: paternally-expressed gene 3 protein; Kruppel-type zinc finger protein; zinc finger and SCAN domain-containing protein 24
• UniProt Protein Name: Paternally-expressed gene 3 protein
• Protein Family: Paternally-expressed gene 3 protein
• UniProt Gene Name: PEG3
• UniProt Synonym Gene Names: KIAA0287; ZSCAN24
• UniProt Entry Name: PEG3_HUMAN

NCBI Description

In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2009]

Uniprot Description

PEG3: Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells. Belongs to the krueppel C2H2-type zinc-finger protein family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; C2H2-type zinc finger protein; DNA-binding

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: nucleic acid binding; metal ion binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; in utero embryonic development; apoptosis; multicellular organism growth