Western Blot (WB)
(Western Blot analysis of PDP1 in Human bladder carcinoma tissue using PDP1 Rabbit pAb at dilution 1/300)
Rabbit PDP1 Polyclonal Antibody | anti-PDP1 antibody
PDP1 Rabbit pAb
IHC-P: 1:25-1:100
Western Blot (WB)
(Western Blot analysis of PDP1 in Human bladder carcinoma tissue using PDP1 Rabbit pAb at dilution 1/300)
Western Blot (WB)
(Western Blot analysis of PDP1 in Human bladder carcinoma tissue using PDP1 Rabbit pAb at dilution 1/300)
Immunohistochemistry (IHC)
(Immunohistochemistry of PDP1 in paraffin-embedded Human thyroid cancer tissue using PDP1 Rabbit pAb at dilution 1/25. Predicted cell location: Cytoplasm)
Immunohistochemistry (IHC)
(Immunohistochemistry of PDP1 in paraffin-embedded Human thyroid cancer tissue using PDP1 Rabbit pAb at dilution 1/25. Predicted cell location: Cytoplasm)
NCBI and Uniprot Product Information
NCBI Description
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
Uniprot Description
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
Research Articles on PDP1
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Product Notes
The PDP1 pdp1 (Catalog #AAA4759000) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PDP1 Rabbit pAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PDP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:200-1:1000 IHC-P: 1:25-1:100. Researchers should empirically determine the suitability of the PDP1 pdp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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