Rabbit anti-Human PDLIM4 Polyclonal Antibody | anti-PDLIM4 antibody

PDLIM4 Antibody

Cat. Num. AAA7107031

• Gene Names: PDLIM4; RIL
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >95%, Protein G purified
• Synonyms: PDLIM4; Polyclonal Antibody; PDLIM4 Antibody; PDZ and LIM domain protein 4; LIM protein RIL; Reversion-induced LIM protein; RIL; anti-PDLIM4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G purified
• Form/Format: Liquid
• Sequence Length: 246

• Applicable Applications for anti-PDLIM4 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:5000
• Immunogen: Recombinant Human PDZ and LIM domain protein 4 protein (81-243AA)
• Conjugation: Non-conjugated
• Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
• Preparation and Storage: Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western BlotPositive WB detected in: K562 whole cell lysateAll lanes: PDLIM4 antibody at 6.1ug/mlSecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 36, 26 KDaObserved band size: 36 KDa)

Product Categories/Family for anti-PDLIM4 antibody

Epigenetics and Nuclear Signaling; Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 196162711
• NCBI GeneID: 8572
• NCBI Accession #: NP_001124499.1
• NCBI GenBank Nucleotide #: NM_001131027.1
• UniProt Accession #: P50479; Q53Y39; Q96AT8; Q9BTW8; Q9Y292; B2R8U1
• Molecular Weight: 25,854 Da
• NCBI Official Full Name: PDZ and LIM domain protein 4 isoform 2
• NCBI Official Synonym Full Names: PDZ and LIM domain 4
• NCBI Official Symbol: PDLIM4
• NCBI Official Synonym Symbols: RIL
• NCBI Protein Information: PDZ and LIM domain protein 4
• UniProt Protein Name: PDZ and LIM domain protein 4
• Protein Family: PDZ and LIM domain protein
• UniProt Gene Name: PDLIM4
• UniProt Synonym Gene Names: RIL

NCBI Description

This gene encodes a protein which may be involved in bone development. Mutations in this gene are associated with susceptibility to osteoporosis. [provided by RefSeq, Nov 2009]

Uniprot Description

Isoform 1: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons ().